CP 339818 hydrochloride

Cat. No.: HY-108574 Purity: 99.61%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

CP 339818 hydrochloride is a nonpeptide and selective Kv1.3 (IC₅₀ value of ~200 nM) and Kv1.4 channels blocker. CP 339818 hydrochloride is a significantly less potent blocker of Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2. CP 339818 hydrochloride potently blocks the C-type inactivated conformation of Kv1.3 and suppresses T cell activation.

For research use only. We do not sell to patients.

CP 339818 hydrochloride Chemical Structure

CAS No. : 478341-55-8

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

Kv1.3

200 nM (IC₅₀)

Kv1.4

Molecular Weight

340.89

Formula

C₂₁H₂₅ClN₂

CAS No.

478341-55-8

Appearance

Solid

Color

White to off-white

SMILES

CCCCC/N=C1C=CN(CC2=CC=CC=C2)C3=C\1C=CC=C3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (183.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9335 mL	14.6675 mL	29.3350 mL
5 mM	0.5867 mL	2.9335 mL	5.8670 mL
10 mM	0.2933 mL	1.4667 mL	2.9335 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.61%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (245 KB) HNMR (141 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. A Nguyen, et al. Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol Pharmacol. 1996 Dec;50(6):1672-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9335 mL	14.6675 mL	29.3350 mL	73.3374 mL
	5 mM	0.5867 mL	2.9335 mL	5.8670 mL	14.6675 mL
	10 mM	0.2933 mL	1.4667 mL	2.9335 mL	7.3337 mL
	15 mM	0.1956 mL	0.9778 mL	1.9557 mL	4.8892 mL
	20 mM	0.1467 mL	0.7334 mL	1.4667 mL	3.6669 mL
	25 mM	0.1173 mL	0.5867 mL	1.1734 mL	2.9335 mL
	30 mM	0.0978 mL	0.4889 mL	0.9778 mL	2.4446 mL
	40 mM	0.0733 mL	0.3667 mL	0.7334 mL	1.8334 mL
	50 mM	0.0587 mL	0.2933 mL	0.5867 mL	1.4667 mL
	60 mM	0.0489 mL	0.2445 mL	0.4889 mL	1.2223 mL
	80 mM	0.0367 mL	0.1833 mL	0.3667 mL	0.9167 mL
	100 mM	0.0293 mL	0.1467 mL	0.2933 mL	0.7334 mL