2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide 

Cat. No.: HY-P1324 Purity: 99.25%
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[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.

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[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide Chemical Structure

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide Chemical Structure

CAS No. : 313988-89-5

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1 mg USD 145 In-stock
5 mg USD 360 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide:

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide Related Antibodies

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NPY Y1 receptor NPY Y2 receptor NPY Y4 receptor NPY Y5 receptor

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Description

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake[1].

IC50 & Target[1]

hY5 receptor

0.24 nM (IC50)

hY1 receptor

530 nM (IC50)

hY2 receptor

>500 nM (IC50)

hY4 receptor

51 nM (IC50)

In Vitro

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide has IC50s of 530 nM, >500 nM, 51 nM for binding to the hY1, hY4, hY2 receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide Related Antibodies
In Vivo

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide (0.2, 2 nmol/rat) induces a high amount of food intake in a dose-dependent manner in adult male rats weighing 340-400 g[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

4207.66

Formula

C183H281N57O54S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

GPSQPTYPGDNATPEQMARYYSALRRYINMA{Aib}RQRY-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (23.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2377 mL 1.1883 mL 2.3766 mL
5 mM 0.0475 mL 0.2377 mL 0.4753 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2377 mL 1.1883 mL 2.3766 mL 5.9415 mL
5 mM 0.0475 mL 0.2377 mL 0.4753 mL 1.1883 mL
10 mM 0.0238 mL 0.1188 mL 0.2377 mL 0.5942 mL
15 mM 0.0158 mL 0.0792 mL 0.1584 mL 0.3961 mL
20 mM 0.0119 mL 0.0594 mL 0.1188 mL 0.2971 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide313988-89-5Neuropeptide Y ReceptorNPY receptorInhibitorinhibitorinhibit

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