2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. CR 665

CR 665  (Synonyms: JNJ 38488502; FE 200665)

Cat. No.: HY-P3609 Purity: 99.65%
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CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CR 665 Chemical Structure

CR 665 Chemical Structure

CAS No. : 228546-92-7

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1 mg USD 60 In-stock
5 mg USD 150 In-stock
10 mg USD 240 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

CR 665 Related Antibodies

Top Publications Citing Use of Products

View All Opioid Receptor Isoform Specific Products:

View All Isoforms
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain[1][2].

IC50 & Target

C50: 10.9 nM (κ-opioid)[1]
In Vitro

CR 665 exhibits high peripheral to central nervous system (CNS) selectivity[1].
CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CR 665 Related Antibodies
Molecular Weight

671.83

Formula

C36H49N9O4
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (148.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4885 mL 7.4424 mL 14.8847 mL
5 mM 0.2977 mL 1.4885 mL 2.9769 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4885 mL 7.4424 mL 14.8847 mL 37.2118 mL
5 mM 0.2977 mL 1.4885 mL 2.9769 mL 7.4424 mL
10 mM 0.1488 mL 0.7442 mL 1.4885 mL 3.7212 mL
15 mM 0.0992 mL 0.4962 mL 0.9923 mL 2.4808 mL
20 mM 0.0744 mL 0.3721 mL 0.7442 mL 1.8606 mL
25 mM 0.0595 mL 0.2977 mL 0.5954 mL 1.4885 mL
30 mM 0.0496 mL 0.2481 mL 0.4962 mL 1.2404 mL
40 mM 0.0372 mL 0.1861 mL 0.3721 mL 0.9303 mL
50 mM 0.0298 mL 0.1488 mL 0.2977 mL 0.7442 mL
60 mM 0.0248 mL 0.1240 mL 0.2481 mL 0.6202 mL
80 mM 0.0186 mL 0.0930 mL 0.1861 mL 0.4651 mL
100 mM 0.0149 mL 0.0744 mL 0.1488 mL 0.3721 mL
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CR 665 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CR 665228546-92-7JNJ 38488502 FE 200665CR665CR-665JNJ38488502JNJ-38488502FE200665FE 200665FE-200665Opioid Receptorκ-opioidperipheralpainneurotensinagonistcentral nervous system (CNS)Inhibitorinhibitorinhibit

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