Crisdesalazine (Synonyms: AAD-2004)

Cat. No.: HY-105005 Purity: 98.10%: FAQs
Data Sheet SDS COA Handling Instructions

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Crisdesalazine (AAD-2004) is an anti-inflammatory agent that simultaneously blocks inflammation mediated by free radicals and prostaglandin E2 (PGE2). Crisdesalazine (AAD-2004) can be used to study neurodegeneration in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.

For research use only. We do not sell to patients.

Crisdesalazine Chemical Structure

CAS No. : 927685-43-6

Size	Price	Stock	Quantity
1 mg	USD 168	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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References
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Description

Molecular Weight

325.28

Formula

C₁₆H₁₄F₃NO₃

CAS No.

927685-43-6

Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC(NCCC2=CC=C(C(F)(F)F)C=C2)=CC=C1O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (153.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0743 mL	15.3714 mL	30.7427 mL
5 mM	0.6149 mL	3.0743 mL	6.1485 mL
10 mM	0.3074 mL	1.5371 mL	3.0743 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.10%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (246 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Shin JH, et al. Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0743 mL	15.3714 mL	30.7427 mL	76.8569 mL
	5 mM	0.6149 mL	3.0743 mL	6.1485 mL	15.3714 mL
	10 mM	0.3074 mL	1.5371 mL	3.0743 mL	7.6857 mL
	15 mM	0.2050 mL	1.0248 mL	2.0495 mL	5.1238 mL
	20 mM	0.1537 mL	0.7686 mL	1.5371 mL	3.8428 mL
	25 mM	0.1230 mL	0.6149 mL	1.2297 mL	3.0743 mL
	30 mM	0.1025 mL	0.5124 mL	1.0248 mL	2.5619 mL
	40 mM	0.0769 mL	0.3843 mL	0.7686 mL	1.9214 mL
	50 mM	0.0615 mL	0.3074 mL	0.6149 mL	1.5371 mL
	60 mM	0.0512 mL	0.2562 mL	0.5124 mL	1.2809 mL
	80 mM	0.0384 mL	0.1921 mL	0.3843 mL	0.9607 mL
	100 mM	0.0307 mL	0.1537 mL	0.3074 mL	0.7686 mL

Crisdesalazine Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crisdesalazine927685-43-6AAD-2004AAD2004AAD 2004OthersAmyotrophic lateral sclerosis (ALS),Inhibitorinhibitorinhibit

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