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Crisdesalazine  (Synonyms: AAD-2004)

Cat. No.: HY-105005 Purity: 98.10%
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Crisdesalazine (AAD-2004) is an anti-inflammatory agent that simultaneously blocks inflammation mediated by free radicals and prostaglandin E2 (PGE2). Crisdesalazine (AAD-2004) can be used to study neurodegeneration in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.

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Crisdesalazine Chemical Structure

Crisdesalazine Chemical Structure

CAS No. : 927685-43-6

Size Price Stock Quantity
1 mg USD 168 In-stock
5 mg USD 420 In-stock
10 mg USD 650 In-stock
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Crisdesalazine Related Antibodies

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Description

Crisdesalazine (AAD-2004) is an anti-inflammatory agent that simultaneously blocks inflammation mediated by free radicals and prostaglandin E2 (PGE2). Crisdesalazine (AAD-2004) can be used to study neurodegeneration in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases[1].

Molecular Weight

325.28

Formula

C16H14F3NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC(NCCC2=CC=C(C(F)(F)F)C=C2)=CC=C1O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (153.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0743 mL 15.3714 mL 30.7427 mL
5 mM 0.6149 mL 3.0743 mL 6.1485 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0743 mL 15.3714 mL 30.7427 mL 76.8569 mL
5 mM 0.6149 mL 3.0743 mL 6.1485 mL 15.3714 mL
10 mM 0.3074 mL 1.5371 mL 3.0743 mL 7.6857 mL
15 mM 0.2050 mL 1.0248 mL 2.0495 mL 5.1238 mL
20 mM 0.1537 mL 0.7686 mL 1.5371 mL 3.8428 mL
25 mM 0.1230 mL 0.6149 mL 1.2297 mL 3.0743 mL
30 mM 0.1025 mL 0.5124 mL 1.0248 mL 2.5619 mL
40 mM 0.0769 mL 0.3843 mL 0.7686 mL 1.9214 mL
50 mM 0.0615 mL 0.3074 mL 0.6149 mL 1.5371 mL
60 mM 0.0512 mL 0.2562 mL 0.5124 mL 1.2809 mL
80 mM 0.0384 mL 0.1921 mL 0.3843 mL 0.9607 mL
100 mM 0.0307 mL 0.1537 mL 0.3074 mL 0.7686 mL
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Crisdesalazine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crisdesalazine927685-43-6AAD-2004AAD2004AAD 2004OthersAmyotrophic lateral sclerosis (ALS),Inhibitorinhibitorinhibit

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