CS-6253 

CS-6253 is an agonist for ATP-binding cassette 1 (ABCA 1). CS-6253 improves the amyloid-β42/40 ratio, and affects lipoprotein metabolism in plasma. CS-6253 generates cholesterol-rich high-density lipoprotein (HDL) particles, and induces the release of microparticles^[1][2].

3055.48

C₁₃₆H₂₂₈N₃₆O₄₃

1627911-44-7

Solid

White to off-white

Glu-Val-{Cit}-Ser-Lys-Leu-Glu-Glu-Trp-Leu-Ala-Ala-Leu-{Cit}-Glu-Leu-Ala-Glu-Glu-Leu-Leu-Ala-Arg-Leu-Lys-Ser

EV-{Cit}-SKLEEWLAAL-{Cit}-ELAEELLARLKS

C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)N)=O)C(C)C)=O)CCCNC(N)=O)=O)CO)=O)CCCCN)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CCCCN)=O)CC(C)C)=O)CCCNC(=N)N)=O)C)=O)CC(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O)CCC(O)=O)=O)CCCNC(N)=O)=O)CC(C)C)=O)C)=O)C)=O)CC(C)C)=O)C=1C=2C(NC1)=CC=CC2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Noveir SD, et al., Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys. Alzheimers Res Ther. 2022 Jun 24;14(1):87.  [Content Brief]

  [2]. Hafiane A, et al., ABCA1 Agonist Mimetic Peptide CS-6253 Induces Microparticles Release From Different Cell Types by ABCA1-Efflux-Dependent Mechanism. Can J Cardiol. 2019 Jun;35(6):770-781.  [Content Brief]