CSNK1-IN-1 

CSNK1-IN-1 is a CSNK1A1 inhibitor. CSNK1-IN-1 has inhibitory activity for CSNK1A1 kinase with IC₅₀ values of 21 μM. CSNK1-IN-1 can be used for the research of proliferative disorders^[1].

IC50: 21 μM (CSNK1A1 kinase)^[1]

CSNK1-IN-1 has inhibitory activity for CSNK1A1, CSNK1D and CSNK1A1 (in high ATP) with IC₅₀ values of 21μM, 29.7μM and 1.5 nM, respectively^[1].
CSNK1-IN-1 shows low inhibition for wild type-EGFR kinase with an IC₅₀ value of ＞20 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

533.54

C₂₉H₂₆F₃N₅O₂

2468784-55-4

Solid

Light yellow to yellow

O=C(N(CC1)C)C2=C1NC(C3=CC=NC(NC([C@@H](C4=CC=C(C=C4)F)CC(F)F)=O)=C3)=C2NC5=CC=CC=C5

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Volker Schulze, et al. 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as csnk1 inhibitors. Patent. WO2020161257 A1.