[Cu2Cl2(4'-(4-Methoxy-1-naphthyl)-terpy)2](PF6)2

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[Cu2Cl2(4'-(4-Methoxy-1-naphthyl)-terpy)2](PF6)2 (Compound 3) is a copper complex, which inhibits cell viability of HCT116, HCT116DoxR, A2780 and fibroblasts, with IC₅₀s of 0.13, 0.15, 0.66 and 6.24 μM, respectively. [Cu2Cl2(4'-(4-Methoxy-1-naphthyl)-terpy)2](PF6)2 induces apoptosis and autophagy, and arrests cell cycle at G0/G1 phase in HCT116DoxR. [Cu2Cl2(4'-(4-Methoxy-1-naphthyl)-terpy)2](PF6)2 exhibits antimetastatic efficacy.

For research use only. We do not sell to patients.

[Cu2Cl2(4'-(4-Methoxy-1-naphthyl)-terpy)2](PF6)2 Chemical Structure

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Description	[Cu2Cl2(4'-(4-Methoxy-1-naphthyl)-terpy)2](PF6)2 (Compound 3) is a copper complex, which inhibits cell viability of HCT116, HCT116DoxR, A2780 and fibroblasts, with IC₅₀s of 0.13, 0.15, 0.66 and 6.24 μM, respectively. [Cu2Cl2(4'-(4-Methoxy-1-naphthyl)-terpy)2](PF6)2 induces apoptosis and autophagy, and arrests cell cycle at G0/G1 phase in HCT116DoxR. [Cu2Cl2(4'-(4-Methoxy-1-naphthyl)-terpy)2](PF6)2 exhibits antimetastatic efficacy^[1].
Molecular Weight	1266.82
Formula	C₅₂H₃₈Cl₂Cu₂F₁₂N₆O₂P₂^2-
SMILES	COC1=C2C(C=CC=C2)=C(C=C1)C3=CC(C4=[N]5C=CC=C4)=[N]6C(C7=CC=CC=[N]7[Cu]658Cl[Cu]9%10([N]%11=CC=CC=C%11C%12=CC(C%13=C%14C=CC=CC%14=C(C=C%13)OC)=CC(C%15=CC=CC=[N]%15%10)=[N]%129)Cl8)=C3.[F-][P+5]([F-])([F-])([F-])([F-])[F-].[F-][P+5]([F-])([F-])([F-])([F-])[F-].[2+]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)
References	[1]. Choroba K, et al., Copper(II) Complexes with 2,2':6',2″-Terpyridine Derivatives Displaying Dimeric Dichloro-μ-Bridged Crystal Structure: Biological Activities from 2D and 3D Tumor Spheroids to In Vivo Models. J Med Chem. 2024 Apr 11;67(7):5813-5836. [Content Brief]