2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. Curcumin 5-8

Curcumin 5-8  (Synonyms: CUR5-8)

Cat. No.: HY-148598 Purity: 98.58%
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Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity.

For research use only. We do not sell to patients.

Curcumin 5-8 Chemical Structure

Curcumin 5-8 Chemical Structure

CAS No. : 890984-26-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 104 In-stock
Solution
10 mM * 1 mL in DMSO USD 104 In-stock
Solid
5 mg USD 95 In-stock
10 mg USD 150 In-stock
25 mg USD 320 In-stock
50 mg USD 510 In-stock
100 mg USD 820 In-stock
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Based on 1 publication(s) in Google Scholar

Curcumin 5-8 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity[1].

In Vitro

Curcumin 5-8 (20 µM; 24 h) decreases PA (palmitic acid (HY-N0830))-induced SREBP1 expression levels and increases Bcl2/BAX expression in AML12 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Curcumin 5-8 Related Antibodies

Western Blot Analysis[1]

Cell Line: AML12 cells
Concentration: 20 µM
Incubation Time: 24 h
Result: Significantly decreased PA-induced SREBP1 expression levels, increased Bcl2/BAX expression.
In Vivo

urcumin 5-8 (100 mg/kg; diet; daily for 13 weeks) ameliorates insulin resistance and hepatic steatosis in mice with HFD (high-fat diet)-induced obesity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old males, 20 g, C57BL/6 mice[1]
Dosage: 100 mg/kg
Administration: Diet; daily for 13 weeks
Result: Significantly suppressed the increases in the insulin level and HOMA-IR.
Molecular Weight

339.39

Formula

C20H21NO4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC(NC(C(C)C)=O)=CC=C1)/C=C/C2=CC=C(C(OC)=C2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (294.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9465 mL 14.7323 mL 29.4646 mL
5 mM 0.5893 mL 2.9465 mL 5.8929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9465 mL 14.7323 mL 29.4646 mL 73.6616 mL
5 mM 0.5893 mL 2.9465 mL 5.8929 mL 14.7323 mL
10 mM 0.2946 mL 1.4732 mL 2.9465 mL 7.3662 mL
15 mM 0.1964 mL 0.9822 mL 1.9643 mL 4.9108 mL
20 mM 0.1473 mL 0.7366 mL 1.4732 mL 3.6831 mL
25 mM 0.1179 mL 0.5893 mL 1.1786 mL 2.9465 mL
30 mM 0.0982 mL 0.4911 mL 0.9822 mL 2.4554 mL
40 mM 0.0737 mL 0.3683 mL 0.7366 mL 1.8415 mL
50 mM 0.0589 mL 0.2946 mL 0.5893 mL 1.4732 mL
60 mM 0.0491 mL 0.2455 mL 0.4911 mL 1.2277 mL
80 mM 0.0368 mL 0.1842 mL 0.3683 mL 0.9208 mL
100 mM 0.0295 mL 0.1473 mL 0.2946 mL 0.7366 mL
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Curcumin 5-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Curcumin 5-8890984-26-6CUR5-8ApoptosisAutophagyautophagyapoptosislipid dropletSREBP1AML12 cellsinsulin resistanceorally activeInhibitorinhibitorinhibit

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