2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. CXCR2 antagonist 3

CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues.

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CXCR2 antagonist 3 Chemical Structure

CXCR2 antagonist 3 Chemical Structure

CAS No. : 2647464-92-2

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CXCR2 antagonist 3 Related Antibodies

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Description

CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues[1].

Cellular Effect
Cell Line Type Value Description References
BXPC-3 IC50
> 10 μM
Compound: 11h
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34676759]
MIA PaCa-2 IC50
> 10 μM
Compound: 11h
Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34676759]
PANC-1 IC50
> 10 μM
Compound: 11h
Cytotoxicity against human PanC-1 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human PanC-1 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34676759]
PBMC IC50
> 10 μM
Compound: 11h
Cytotoxicity against human PBMC cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human PBMC cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34676759]
SW1990 IC50
> 10 μM
Compound: 11h
Cytotoxicity against human SW1990 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human SW1990 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34676759]
Molecular Weight

362.38

Formula

C17H15FN2O4S
CAS No.
SMILES

O=S1(C2=C(O)C(NC(NC3=CC=CC(F)=C3C)=O)=CC=C2C=CC1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CXCR2 antagonist 3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CXCR2 antagonist 32647464-92-2CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXC chemokine receptorneutrophilCD3+T lymphocytesPan02 tumorInhibitorinhibitorinhibit

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CXCR2 antagonist 3
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