2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CXCR HIV
  4. CXCR4 antagonist 7

CXCR4 antagonist 7 (Compound PARA-B) is a CXCR4 antagonist with the IC50 of 9.3 nM. CXCR4 antagonist 7 can be used for the research of HIV infection, inflammatory diseases, cancer, and WHIM syndrome.

For research use only. We do not sell to patients.

CXCR4 antagonist 7 Chemical Structure

CXCR4 antagonist 7 Chemical Structure

CAS No. : 1185451-72-2

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CXCR4 antagonist 7 Related Antibodies

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Description

CXCR4 antagonist 7 (Compound PARA-B) is a CXCR4 antagonist with the IC50 of 9.3 nM. CXCR4 antagonist 7 can be used for the research of HIV infection, inflammatory diseases, cancer, and WHIM syndrome[1].

IC50 & Target

CXCR4/CXCL12

9.3 nM (IC50)

In Vitro

CXCR4 antagonist 7 (PARA-B, 10 nM-1 μM, 20 h) inhibits CXCL12-induced GH4C1 cell proliferation with an IC50 value of 9.3 nM[1].
CXCR4 antagonist 7 (1 μM, 12 h) inhibits CXCL12-dependent GH4C1 cell migration with inhibition rate of 50%[1].
CXCR4 antagonist 7 (50 nM, 30 min) reduces ERK1/2 phosphorylation induced by CXCL12[1].
CXCR4 antagonist 7 (50 nM-1 μM, 30 min) acts via CXCR4 antagonism to revert CXCL12 induction of GH4C1 proliferation and migration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CXCR4 antagonist 7 Related Antibodies

Cell Viability Assay[1]

Cell Line: GH4C1 cell (48 h of serum deprivation)
Concentration: 1 μM
Incubation Time: 24 h
Result: Had no effect on cell viability of GH4C1 cell.

Cell Proliferation Assay[1]

Cell Line: GH4C1 cell ( FBS-starved GH4C1 cells treated with CXCL12 (25 nM) for 12 h)
Concentration: 10 nM-1 μM
Incubation Time: 20 h, 24 h
Result: Inhibited proliferation of multiple cancer cell lines with IC50 value ranging from 1.08 to 3.45 μM, and had no effect on cell viability of GH4C1cell.

Cell Migration Assay [1]

Cell Line: GH4C1 and GH4A11 cells (FBS-starved cells treated with CXCL12 (25 nM) for 48 h)
Concentration: 50 nM-1 μM
Incubation Time: 12 h for GH4C1, 30 min for GH4A11
Result: Reduced the number of migrating GH4C1 cells significantly, had no effect on GH4A11 cell (CRISPR-CAS9, reduction in CXCR4 mRNA) migration.

Western Blot Analysis[1]

Cell Line: GH4C1 cell (FBS-starved cells treated with CXCL12 (25 nM) for 15 min)
Concentration: 50 nM
Incubation Time: 30 min
Result: Reduced ERK1/2 phosphorylation induced by CXCL12.
Molecular Weight

315.33

Formula

C15H17N5O3
CAS No.
SMILES

O=C(N(C(N/1)=O)/C=C/C2=CC=C(O)C=C2)C1=C\CC/N=C(N)/N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CXCR4 antagonist 7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CXCR4 antagonist 71185451-72-2CXCRHIVCXC chemokine receptorsC-X-C motif chemokine receptorsHuman immunodeficiency virusCXCR4 antagonistHIV infectioninflammatory diseasescancerWHIM syndromeHydantoin alkaloidParazoanthineInhibitorinhibitorinhibit

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