2. Cytoskeleton
  3. Integrin
  4. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro)

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro)  (Synonyms: c(GRGDSP))

Cat. No.: HY-P5038 Purity: 98.11%
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Handling Instructions Technical Support

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 integrin ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) Chemical Structure

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) Chemical Structure

CAS No. : 135432-37-0

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Based on 1 publication(s) in Google Scholar

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) Related Antibodies

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View All Integrin Isoform Specific Products:

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 integrin ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells[1].

Molecular Weight

569.57

Formula

C22H35N9O9
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro)
Sequence Shortening

Cyclo(GRGDSP)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (175.57 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7557 mL 8.7786 mL 17.5571 mL
5 mM 0.3511 mL 1.7557 mL 3.5114 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7557 mL 8.7786 mL 17.5571 mL 43.8928 mL
5 mM 0.3511 mL 1.7557 mL 3.5114 mL 8.7786 mL
10 mM 0.1756 mL 0.8779 mL 1.7557 mL 4.3893 mL
15 mM 0.1170 mL 0.5852 mL 1.1705 mL 2.9262 mL
20 mM 0.0878 mL 0.4389 mL 0.8779 mL 2.1946 mL
25 mM 0.0702 mL 0.3511 mL 0.7023 mL 1.7557 mL
30 mM 0.0585 mL 0.2926 mL 0.5852 mL 1.4631 mL
40 mM 0.0439 mL 0.2195 mL 0.4389 mL 1.0973 mL
50 mM 0.0351 mL 0.1756 mL 0.3511 mL 0.8779 mL
60 mM 0.0293 mL 0.1463 mL 0.2926 mL 0.7315 mL
80 mM 0.0219 mL 0.1097 mL 0.2195 mL 0.5487 mL
100 mM 0.0176 mL 0.0878 mL 0.1756 mL 0.4389 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro)135432-37-0c(GRGDSP)Integrininhibitory peptideInhibitorinhibitorinhibit

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