Cyclo(Gly-L-Pro)

Cat. No.: HY-P1936: FAQs
Data Sheet Handling Instructions

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Cyclo(Gly-L-Pro) is a Alkaloids product that can be isolated from the roots of Panax notoginseng (Burk.)F.H.Chen.

For research use only. We do not sell to patients.

Cyclo(Gly-L-Pro) Chemical Structure

CAS No. : 3705-27-9

Size	Price	Stock	Quantity
5 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

Cyclo(Gly-L-Pro) is a Alkaloids product that can be isolated from the roots of Panax notoginseng (Burk.)F.H.Chen^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	4.5 μg/mL Compound: 1	Inhibition of LPS-induced TNF-alpha production in mouse RAW264.7 cells pretreated with compound for 1 hr followed by addition of 1 ug/ml LPS for 6 hrs by ELISA Inhibition of LPS-induced TNF-alpha production in mouse RAW264.7 cells pretreated with compound for 1 hr followed by addition of 1 ug/ml LPS for 6 hrs by ELISA	[PMID: 26546220]

Molecular Weight

154.17

Formula

C₇H₁₀N₂O₂

CAS No.

3705-27-9

Appearance

Solid

Sequence

Cyclo(Pro-Gly)

Sequence Shortening

Cyclo(PG)

SMILES

O=C1[C@@]2([H])N(CCC2)C(CN1)=O

Structure Classification

Alkaloids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Stored under nitrogen, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 200 mg/mL (1297.27 mM)

DMSO : 25 mg/mL (162.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.4863 mL	32.4317 mL	64.8635 mL
5 mM	1.2973 mL	6.4863 mL	12.9727 mL
10 mM	0.6486 mL	3.2432 mL	6.4863 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	6.4863 mL	32.4317 mL	64.8635 mL	162.1587 mL
	5 mM	1.2973 mL	6.4863 mL	12.9727 mL	32.4317 mL
	10 mM	0.6486 mL	3.2432 mL	6.4863 mL	16.2159 mL
	15 mM	0.4324 mL	2.1621 mL	4.3242 mL	10.8106 mL
	20 mM	0.3243 mL	1.6216 mL	3.2432 mL	8.1079 mL
	25 mM	0.2595 mL	1.2973 mL	2.5945 mL	6.4863 mL
	30 mM	0.2162 mL	1.0811 mL	2.1621 mL	5.4053 mL
	40 mM	0.1622 mL	0.8108 mL	1.6216 mL	4.0540 mL
	50 mM	0.1297 mL	0.6486 mL	1.2973 mL	3.2432 mL
	60 mM	0.1081 mL	0.5405 mL	1.0811 mL	2.7026 mL
	80 mM	0.0811 mL	0.4054 mL	0.8108 mL	2.0270 mL
	100 mM	0.0649 mL	0.3243 mL	0.6486 mL	1.6216 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Cyclo(Gly-L-Pro) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(Gly-L-Pro)3705-27-9OthersInhibitorinhibitorinhibit

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