2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP1B1 ligand 3

CYP1B1 ligand 3 (Compound A1) is a selective inhibitor for cytochrome P450 enzyme CYP1B1 with an IC50 of 11.9 nM. CYP1B1 ligand 3 can be utilized for the synthesis of PROTAC CYP1B1 degrader-2 (HY-158429).

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CYP1B1 ligand 3 Chemical Structure

CYP1B1 ligand 3 Chemical Structure

CAS No. : 65823-65-6

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CYP1B1 ligand 3 Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

CYP1B1 ligand 3 (Compound A1) is a selective inhibitor for cytochrome P450 enzyme CYP1B1 with an IC50 of 11.9 nM. CYP1B1 ligand 3 can be utilized for the synthesis of PROTAC CYP1B1 degrader-2 (HY-158429)[1].

IC50 & Target

CYP1B1

11.9 nM (IC50)

CYP1A1

278.7 nM (IC50)

CYP1A2

3913.5 nM (IC50)

Molecular Weight

369.89

Formula

C18H12ClN3S2
CAS No.
SMILES

ClC1=CC=C(NC2=NC(C3=NC(C4=CC=CC=C4)=CS3)=CS2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CYP1B1 ligand 3 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP1B1 ligand 365823-65-6Cytochrome P450CYPsA549NSCLCtaxol resistantnon-small cell lung cancerInhibitorinhibitorinhibit

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