2. Autophagy
  3. Autophagy
  4. Cytochalasin E

Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation.

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Cytochalasin E Chemical Structure

Cytochalasin E Chemical Structure

CAS No. : 36011-19-5

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Based on 1 publication(s) in Google Scholar

Cytochalasin E Related Antibodies

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Description

Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.0062 μM
Compound: 4
Cytotoxicity against human A549 cells after 72 hrs by MTT method
Cytotoxicity against human A549 cells after 72 hrs by MTT method
[PMID: 16792402]
HUVEC IC50
0.0114 μM
Compound: 7
Antiangiogenesis activity in HUVEC assessed as inhibition of VEGF-induced cell proliferation after 72 hrs by MTT assay
Antiangiogenesis activity in HUVEC assessed as inhibition of VEGF-induced cell proliferation after 72 hrs by MTT assay
[PMID: 21718054]
P388 IC50
0.093 μM
Compound: 4
Cytotoxicity against mouse P388 cells after 72 hrs by MTT method
Cytotoxicity against mouse P388 cells after 72 hrs by MTT method
[PMID: 16792402]
In Vitro

Cytochalasin E prominently inhibits the growth of A549 cells in a dose-dependent manner[3].
Cytochalasin E could induce the up-regulation of autophagy-related protein (LC3-II) and SQSTM1/p62[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cytochalasin E Related Antibodies
Molecular Weight

495.56

Formula

C28H33NO7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@]2(O3)[C@]([C@@H]([C@](O4)(C)[C@@H]4[C@]2([H])/C=C/C[C@@H](C([C@](C)(O)/C=C/OC3=O)=O)C)C)([H])[C@H](CC5=CC=CC=C5)N1
Structure Classification
Initial Source

the fungus R. necatrix
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (100.90 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0179 mL 10.0896 mL 20.1792 mL
5 mM 0.4036 mL 2.0179 mL 4.0358 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.90%

SDS (251 KB)

COA (256 KB) RP-HPLC (916 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0179 mL 10.0896 mL 20.1792 mL 50.4480 mL
5 mM 0.4036 mL 2.0179 mL 4.0358 mL 10.0896 mL
10 mM 0.2018 mL 1.0090 mL 2.0179 mL 5.0448 mL
15 mM 0.1345 mL 0.6726 mL 1.3453 mL 3.3632 mL
20 mM 0.1009 mL 0.5045 mL 1.0090 mL 2.5224 mL
25 mM 0.0807 mL 0.4036 mL 0.8072 mL 2.0179 mL
30 mM 0.0673 mL 0.3363 mL 0.6726 mL 1.6816 mL
40 mM 0.0504 mL 0.2522 mL 0.5045 mL 1.2612 mL
50 mM 0.0404 mL 0.2018 mL 0.4036 mL 1.0090 mL
60 mM 0.0336 mL 0.1682 mL 0.3363 mL 0.8408 mL
80 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.6306 mL
100 mM 0.0202 mL 0.1009 mL 0.2018 mL 0.5045 mL
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Cytochalasin E Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cytochalasin E36011-19-5AutophagyInhibitorinhibitorinhibit

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