1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Cytosine-d2

Cytosine-d2 is the deuterium labeled Cytosine[1]. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging[2][3].

For research use only. We do not sell to patients.

Cytosine-d<sub>2</sub> Chemical Structure

Cytosine-d2 Chemical Structure

CAS No. : 106391-24-6

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Based on 1 publication(s) in Google Scholar

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Description

Cytosine-d2 is the deuterium labeled Cytosine[1]. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging[2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

113.11

Formula

C4H3D2N3O

CAS No.
Unlabeled CAS

71-30-7

Appearance

Solid

Color

White to off-white

SMILES

NC(N1)=C([2H])C([2H])=NC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (88.41 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.8410 mL 44.2048 mL 88.4095 mL
5 mM 1.7682 mL 8.8410 mL 17.6819 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 8.8410 mL 44.2048 mL 88.4095 mL 221.0238 mL
5 mM 1.7682 mL 8.8410 mL 17.6819 mL 44.2048 mL
10 mM 0.8841 mL 4.4205 mL 8.8410 mL 22.1024 mL
15 mM 0.5894 mL 2.9470 mL 5.8940 mL 14.7349 mL
20 mM 0.4420 mL 2.2102 mL 4.4205 mL 11.0512 mL
25 mM 0.3536 mL 1.7682 mL 3.5364 mL 8.8410 mL
30 mM 0.2947 mL 1.4735 mL 2.9470 mL 7.3675 mL
40 mM 0.2210 mL 1.1051 mL 2.2102 mL 5.5256 mL
50 mM 0.1768 mL 0.8841 mL 1.7682 mL 4.4205 mL
60 mM 0.1473 mL 0.7367 mL 1.4735 mL 3.6837 mL
80 mM 0.1105 mL 0.5526 mL 1.1051 mL 2.7628 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Cytosine-d2
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HY-I0626S2
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