2. Autophagy
  3. LRRK2
  4. CZC-54252 hydrochloride

CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM.CZC-54252 hydrochloride has a neuroprotective activity.

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CZC-54252 hydrochloride Chemical Structure

CZC-54252 hydrochloride Chemical Structure

CAS No. : 1784253-05-9

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10 mg USD 144 In-stock
50 mg USD 460 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM.CZC-54252 hydrochloride has a neuroprotective activity[1].

IC50 & Target

IC50: 1.28 nM (Wild-type LRRK2) and 1.85 nM (G2019S LRRK2)[1]
Molecular Weight

541.45

Formula

C22H26Cl2N6O4S
CAS No.
Appearance

Solid

Color

Light yellow to orange

SMILES

CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (61.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8469 mL 9.2345 mL 18.4689 mL
5 mM 0.3694 mL 1.8469 mL 3.6938 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8469 mL 9.2345 mL 18.4689 mL 46.1723 mL
5 mM 0.3694 mL 1.8469 mL 3.6938 mL 9.2345 mL
10 mM 0.1847 mL 0.9234 mL 1.8469 mL 4.6172 mL
15 mM 0.1231 mL 0.6156 mL 1.2313 mL 3.0782 mL
20 mM 0.0923 mL 0.4617 mL 0.9234 mL 2.3086 mL
25 mM 0.0739 mL 0.3694 mL 0.7388 mL 1.8469 mL
30 mM 0.0616 mL 0.3078 mL 0.6156 mL 1.5391 mL
40 mM 0.0462 mL 0.2309 mL 0.4617 mL 1.1543 mL
50 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9234 mL
60 mM 0.0308 mL 0.1539 mL 0.3078 mL 0.7695 mL
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CZC-54252 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CZC-542521784253-05-9CZC54252CZC 54252LRRK2Leucine-rich repeat kinase 2neuroprotectiveneuronalinjuryLRRK2-G2019SInhibitorinhibitorinhibit

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