CZC-54252 hydrochloride

Cat. No.: HY-B0792A Purity: 98.44%: FAQs
Data Sheet SDS COA Handling Instructions

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CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC₅₀s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC₅₀ of ~1 nM.CZC-54252 hydrochloride has a neuroprotective activity.

For research use only. We do not sell to patients.

CZC-54252 hydrochloride Chemical Structure

CAS No. : 1784253-05-9

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 107	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 107	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 144	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 460	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of CZC-54252 hydrochloride:

CZC-54252 In-stock

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: 1.28 nM (Wild-type LRRK2) and 1.85 nM (G2019S LRRK2)^[1]

Molecular Weight

541.45

Formula

C₂₂H₂₆Cl₂N₆O₄S

CAS No.

1784253-05-9

Appearance

Solid

Color

Light yellow to orange

SMILES

CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (61.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8469 mL	9.2345 mL	18.4689 mL
5 mM	0.3694 mL	1.8469 mL	3.6938 mL
10 mM	0.1847 mL	0.9234 mL	1.8469 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.44%

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Data Sheet (272 KB) SDS (251 KB)

COA (249 KB) HNMR (308 KB) LCMS (278 KB)

Handling Instructions (2659 KB)

References

[1]. Nigel Ramsden, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8469 mL	9.2345 mL	18.4689 mL	46.1723 mL
	5 mM	0.3694 mL	1.8469 mL	3.6938 mL	9.2345 mL
	10 mM	0.1847 mL	0.9234 mL	1.8469 mL	4.6172 mL
	15 mM	0.1231 mL	0.6156 mL	1.2313 mL	3.0782 mL
	20 mM	0.0923 mL	0.4617 mL	0.9234 mL	2.3086 mL
	25 mM	0.0739 mL	0.3694 mL	0.7388 mL	1.8469 mL
	30 mM	0.0616 mL	0.3078 mL	0.6156 mL	1.5391 mL
	40 mM	0.0462 mL	0.2309 mL	0.4617 mL	1.1543 mL
	50 mM	0.0369 mL	0.1847 mL	0.3694 mL	0.9234 mL
	60 mM	0.0308 mL	0.1539 mL	0.3078 mL	0.7695 mL