2. Apoptosis
  3. Caspase
  4. CZL80

CZL80, a brain-penetrable caspase-1 inhibitor with an IC50 of 0.01 μM, could be used in the study of febrile seizures and later enhanced epileptogenic susceptibility.

For research use only. We do not sell to patients.

CZL80 Chemical Structure

CZL80 Chemical Structure

CAS No. : 313482-91-6

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

CZL80 Related Antibodies

Top Publications Citing Use of Products

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CZL80, a brain-penetrable caspase-1 inhibitor with an IC50 of 0.01 μM, could be used in the study of febrile seizures and later enhanced epileptogenic susceptibility[1].

IC50 & Target[1].

Caspase-1

0.01 μM (IC50)

In Vivo

CZL80 (7.5 mg/kg, i.v., qod) markedly reduces neuronal excitability and incidence of FS generation, and, in adult mice, relieved later enhanced epileptogenic susceptibility[1].
CZL80 delayed-administration is a competent to attenuate the progressive neurological dysfunction induced by photothrombosis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice and Caspase-1 gene knockout (Caspase-1−/−) mice weighing 23-26 g (9-10 weeks old)[2].
Dosage: 10, 30 mg/kg/d, 7 days.
Administration: i.p.
Result: Rescued motor dysfunction after photothrombotic stroke in mice.
Animal Model: Mice pups of caspase-1 knockout (Casp1−/−, RRID:IMSR_JAX:004947) and littermate controls (wild-type [WT], Casp1+/+)[1].
Dosage: 0.0075, 0.075, 0.75 and 7.5 mg/kg (2% DMSO in saline), qod (every other day).
Administration: Intravenously injected.
Result: Reduced seizure incidence, prolonged seizure latency and increased threshold to FS generation in a dose-dependent manner.
Molecular Weight

366.39

Formula

C19H14N2O4S
CAS No.
SMILES

O=C(O)C1=CC=CC(NC(C2=CC=CC(NC(C3=CC=CS3)=O)=C2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    CZL80 is dissolved in mixed solvent (propylene glycol:ethanol:water=5:1:4)[2].

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CZL80 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CZL80313482-91-6CZL 80CZL-80CaspaseFebrile seizurecaspase-1,Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CZL80
Cat. No.:
HY-131204
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.