D-myo-Inositol-1,4,5-triphosphate trisodium  (Synonyms: Inositol 1,4,5-trisphosphate trisodium; Ins(1,4,5)-P3 trisodium)

D-myo-Inositol-1,4,5-triphosphate sodium salt is the trisodium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum.

Second messenger D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3) is served as an inositol phosphate derivative. The dissociation constant (K_D) for Pr55^Gag complexed with D-myo-Inositol 1,4,5-trisphosphate (an inositol with divalent phosphate groups and devoid of lipid groups) is 2170 μM. The binding affinities of D-myo-Inositol 1,4,5-trisphosphate (K_D=568 μM) and 1,3,4,5-IP4 (K_D=526 μM) for matrix (MA) are almost identical^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

486.04

C₆H₁₂Na₃O₁₅P₃

141611-10-1

Solid

White to off-white

O=P(O)(O[Na])O[C@H]1[C@@H]([C@H]([C@H]([C@H]([C@@H]1O)OP(O)(O[Na])=O)O)O)OP(O)(O[Na])=O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Anraku K, et al. Highly sensitive analysis of the interaction between HIV-1 Gag and phosphoinositide derivatives based on surface plasmon resonance. Biochemistry. 2010 Jun 29;49(25):5109-16.  [Content Brief]