D-α-Tocopherol Succinate (Synonyms: Vitamin E succinate)

Name: D-α-Tocopherol Succinate
Brand: MedChemExpress
SKU: HY-131553
Rating: 5.0 (2 reviews)

Cat. No.: HY-131553 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer.

For research use only. We do not sell to patients.

D-α-Tocopherol Succinate Chemical Structure

CAS No. : 4345-03-3

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Based on 2 publication(s) in Google Scholar

Other Forms of D-α-Tocopherol Succinate:

D-α-Tocopherol Succinate (Standard) Get quote

2 Publications Citing Use of MCE D-α-Tocopherol Succinate

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Biological Activity
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References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	10 μM Compound: 1, VES	Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA	[PMID: 19708661]
HCT-116	IC₅₀	52.3 μM Compound: alpha-TOS	Cytotoxicity against Homo sapiens (human) HCT116 cells after 48 hr by SRB assay Cytotoxicity against Homo sapiens (human) HCT116 cells after 48 hr by SRB assay	10.1007/s00044-011-9801-3
HepG2	IC₅₀	245 μM Compound: alpha-TOS	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27344490]
HepG2	IC₅₀	55 μM Compound: alpha-TOS	Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by SRB assay Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by SRB assay	10.1007/s00044-011-9801-3
MCF7	IC₅₀	57 μM Compound: alpha-TOS	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27344490]
MT4	IC₅₀	66 μM Compound: alpha-TOS	Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27344490]
RPMI-8226	IC₅₀	63 μM Compound: alpha-TOS	Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27344490]
U-937	IC₅₀	113 μM Compound: alpha-TOS	Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27344490]

In Vitro

D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells^[1].
D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity^[1].
D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	HEI-OC1 cell line
Concentration:	1-20 μM
Incubation Time:	24 hours
Result:	Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM.

Cell Viability Assay^[1]

Cell Line:	HEI-OC1 cell line
Concentration:	10 μM
Incubation Time:	48 hours
Result:	Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis.

Cell Cytotoxicity Assay^[2]

Cell Line:	TC-1 tumor cells
Concentration:	0, 25 and 50 μM
Incubation Time:	18 hours
Result:	Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells.

In Vivo

D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cells^[2]
Dosage:	1 and 2 mg/kg
Administration:	Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days
Result:	Dreased the tumor volume, especially with a dose of 2 mg/kg.

Molecular Weight

530.78

Formula

C₃₃H₅₄O₅

CAS No.

4345-03-3

Appearance

Solid

Color

White to off-white

SMILES

CC1=C2C(CC[C@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C(OC(CCC(O)=O)=O)=C1C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (471.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8840 mL	9.4201 mL	18.8402 mL
5 mM	0.3768 mL	1.8840 mL	3.7680 mL
10 mM	0.1884 mL	0.9420 mL	1.8840 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (242 KB) HNMR (270 KB) MS (198 KB)

Handling Instructions (2659 KB)

References

[1]. Kim SK, et al. The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Int J Pediatr Otorhinolaryngol. 2016 Jul;86:9-14. [Content Brief]

[2]. Kang TH, et al. Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects. PLoS One. 2014 Jul 29;9(7):e103562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8840 mL	9.4201 mL	18.8402 mL	47.1005 mL
	5 mM	0.3768 mL	1.8840 mL	3.7680 mL	9.4201 mL
	10 mM	0.1884 mL	0.9420 mL	1.8840 mL	4.7100 mL
	15 mM	0.1256 mL	0.6280 mL	1.2560 mL	3.1400 mL
	20 mM	0.0942 mL	0.4710 mL	0.9420 mL	2.3550 mL
	25 mM	0.0754 mL	0.3768 mL	0.7536 mL	1.8840 mL
	30 mM	0.0628 mL	0.3140 mL	0.6280 mL	1.5700 mL
	40 mM	0.0471 mL	0.2355 mL	0.4710 mL	1.1775 mL
	50 mM	0.0377 mL	0.1884 mL	0.3768 mL	0.9420 mL
	60 mM	0.0314 mL	0.1570 mL	0.3140 mL	0.7850 mL
	80 mM	0.0236 mL	0.1178 mL	0.2355 mL	0.5888 mL
	100 mM	0.0188 mL	0.0942 mL	0.1884 mL	0.4710 mL

D-α-Tocopherol Succinate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-α-Tocopherol4345-03-3Vitamin EApoptosiscisplatinantioxidantototoxicityROSapoptosisTC-1HEI-OC1caspase-3Inhibitorinhibitorinhibit

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D-α-Tocopherol Succinate (Synonyms: Vitamin E succinate)

Customer Review

Other Forms of D-α-Tocopherol Succinate:

D-α-Tocopherol Succinate Related Antibodies

2 Publications Citing Use of MCE D-α-Tocopherol Succinate

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

D-α-Tocopherol Succinate Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

D-α-Tocopherol Succinate Related Classifications

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