Dabcyl-KTSAVLQSGFRKME-Edans TFA

Name: Dabcyl-KTSAVLQSGFRKME-Edans TFA
Brand: MedChemExpress
SKU: HY-P2295
Rating: 4.5 (1 reviews)

Cat. No.: HY-P2295 Purity: 99.75%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Dabcyl-KTSAVLQSGFRKME-Edans TFA Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Dabcyl-KTSAVLQSGFRKME-Edans TFA

•Patent. US20220324800A1.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Recombinant 3CL_pro is expressed in Pichia pastoris GS115 as a 42 kDa protein that displays a K_m of 15 μM with Dabcyl-KTSAVLQSGFRKME-Edans TFA as substrate^[1].
The Dabcyl-KTSAVLQSGFRKME-Edans TFA fluorogenic peptide is used as the substrate and the enhanced fluorescence due to cleavage of this substrate catalyzed by the protease is monitored at 538 nm with an excitation wavelength of 355 nm using a fluorescence plate reader^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2081.43 (free base)

Formula

C₉₅H₁₄₁N₂₅O₂₄S₂.xC₂HF₃O₂

Appearance

Solid

Color

Pink to red

Sequence

Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-Edans

Sequence Shortening

Dabcyl-KTSAVLQSGFRKME-Edans

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 6.67 mg/mL (Need ultrasonic)

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.75%

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Data Sheet (269 KB) SDS (252 KB)

COA (243 KB) LCMS (103 KB) Elemental Analysis Report (101 KB)

Handling Instructions (2659 KB)

References

[1]. Thi Thanh Hanh Nguyen, et al.Flavonoid-mediated Inhibition of SARS Coronavirus 3C-like Protease Expressed in Pichia Pastoris. Biotechnol Lett. 2012 May;34(5):831-8. [Content Brief]

[2]. Chih-Jung Kuo, et al.Engineering a Novel Endopeptidase Based on SARS 3CL(pro). Biotechniques. 2009 Dec;47(6):1029-32. [Content Brief]

[3]. Cheng-Wei Yang, et al.Novel Small-Molecule Inhibitors of Transmissible Gastroenteritis Virus. Antimicrob Agents Chemother. 2007 Nov;51(11):3924-31. [Content Brief]