Danvatirsen  (Synonyms: AZD9150)

Danvatirsen is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth.

5422.00

1402357-06-5

Solid

White to off-white

DNA, d(P-thio)([(5′ξ)-2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-(3′→4′)-[(5′ξ)-2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5U-(3′→4′)-[(5′ξ)-2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-lyxo-hexofurano]A-T-T-T-G-G-A-T-G-T-m5C-(3′→4′)-[(5′ξ)-2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-lyxo-hexofurano]A-(3′→4′)-[(5′ξ)-2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-lyxo-hexofurano]G-(3′→4′)-[(5′ξ)-2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C)

[Danvatirsen]

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Hong D, Kurzrock R, Kim Y, et al. AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer. Sci Transl Med. 2015;7(314):314ra185.  [Content Brief]

  [2]. Reilley MJ, McCoon P, Cook C, et al. STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial. J Immunother Cancer. 2018;6(1):119.  [Content Brief]

  [3]. Odate S, Veschi V, Yan S, Lam N, Woessner R, Thiele CJ. Inhibition of STAT3 with the Generation 2.5 Antisense Oligonucleotide, AZD9150, Decreases Neuroblastoma Tumorigenicity and Increases Chemosensitivity. Clin Cancer Res. 2017;23(7):1771-1784.  [Content Brief]

  [4]. Shastri A, Choudhary G, Teixeira M, et al. Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells. J Clin Invest. 2018;128(12):5479-5488.  [Content Brief]