2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Antibiotic Parasite Bacterial Reactive Oxygen Species
  4. Dapsone-d8

Dapsone-d8  (Synonyms: 4,4′-Diaminodiphenyl sulfone-d8; DDS-d8)

Cat. No.: HY-B0688S Purity: 99.82%
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Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].

For research use only. We do not sell to patients.

Dapsone-d<sub>8</sub> Chemical Structure

Dapsone-d8 Chemical Structure

CAS No. : 557794-38-4

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5 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Dapsone-d8:

Dapsone-d8 Related Antibodies

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Description

Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].

In Vitro

Dapsone (0.06 mM; 30 min) suppresses intra- and extracellular production of superoxide (O2-) and elastase release triggered by N-Formyl-Met-Leu-Phe (HY-P0224) (1 μM) and physiological agonist C5a (100 nM), but not by Phorbol 12-myristate 13-acetate (HY-18739) (100 nM)[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dapsone-d8 Related Antibodies
In Vivo

Dapsone (5 mg/kg; i.p.; single dose) shows neuroprotective effects and substantially improves memory acquisition in Scopolamine (HY-N0296)-induced memory impairment in mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Scopolamine-induced memory impairment model in mice[6]
Dosage: 0.1, 0.3, 1, 5, and 10 mg/kg; 1 mg/kg for Scopolamine
Administration: Intraperitoneal injection; single dose
Result: Improved memory acquisition.
Molecular Weight

256.35

Formula

C12H4D8N2O2S
CAS No.
Unlabeled CAS

80-08-0
Appearance

Solid

Color

White to off-white

SMILES

NC1=C(C([2H])=C(C([2H])=C1[2H])S(C2=C(C([2H])=C(C([2H])=C2[2H])N)[2H])(=O)=O)[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (975.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 250 mg/mL (975.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9009 mL 19.5046 mL 39.0092 mL
5 mM 0.7802 mL 3.9009 mL 7.8018 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 3.9009 mL 19.5046 mL 39.0092 mL 97.5229 mL
5 mM 0.7802 mL 3.9009 mL 7.8018 mL 19.5046 mL
10 mM 0.3901 mL 1.9505 mL 3.9009 mL 9.7523 mL
15 mM 0.2601 mL 1.3003 mL 2.6006 mL 6.5015 mL
20 mM 0.1950 mL 0.9752 mL 1.9505 mL 4.8761 mL
25 mM 0.1560 mL 0.7802 mL 1.5604 mL 3.9009 mL
30 mM 0.1300 mL 0.6502 mL 1.3003 mL 3.2508 mL
40 mM 0.0975 mL 0.4876 mL 0.9752 mL 2.4381 mL
50 mM 0.0780 mL 0.3901 mL 0.7802 mL 1.9505 mL
60 mM 0.0650 mL 0.3251 mL 0.6502 mL 1.6254 mL
80 mM 0.0488 mL 0.2438 mL 0.4876 mL 1.2190 mL
100 mM 0.0390 mL 0.1950 mL 0.3901 mL 0.9752 mL
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Dapsone-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dapsone-d8557794-38-44,4′-Diaminodiphenyl sulfone-d8DDS-d8AntibioticParasiteBacterialReactive Oxygen SpeciesInhibitorinhibitorinhibit

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