2. PROTAC
  3. PROTAC Linkers
  4. DBCO-PEG12-NHS ester

DBCO-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG12-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DBCO-PEG12-NHS ester Chemical Structure

DBCO-PEG12-NHS ester Chemical Structure

CAS No. : 2093934-94-0

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25 mg USD 300 In-stock
50 mg USD 481 In-stock
100 mg USD 770 In-stock
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Based on 1 publication(s) in Google Scholar

DBCO-PEG12-NHS ester Related Antibodies

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Description

DBCO-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG12-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-PEG12-NHS ester Related Antibodies
Molecular Weight

1002.11

Formula

C50H71N3O18
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (99.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9979 mL 4.9895 mL 9.9789 mL
5 mM 0.1996 mL 0.9979 mL 1.9958 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9979 mL 4.9895 mL 9.9789 mL 24.9474 mL
5 mM 0.1996 mL 0.9979 mL 1.9958 mL 4.9895 mL
10 mM 0.0998 mL 0.4989 mL 0.9979 mL 2.4947 mL
15 mM 0.0665 mL 0.3326 mL 0.6653 mL 1.6632 mL
20 mM 0.0499 mL 0.2495 mL 0.4989 mL 1.2474 mL
25 mM 0.0399 mL 0.1996 mL 0.3992 mL 0.9979 mL
30 mM 0.0333 mL 0.1663 mL 0.3326 mL 0.8316 mL
40 mM 0.0249 mL 0.1247 mL 0.2495 mL 0.6237 mL
50 mM 0.0200 mL 0.0998 mL 0.1996 mL 0.4989 mL
60 mM 0.0166 mL 0.0832 mL 0.1663 mL 0.4158 mL
80 mM 0.0125 mL 0.0624 mL 0.1247 mL 0.3118 mL
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DBCO-PEG12-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBCO-PEG12-NHS ester2093934-94-0PROTAC LinkersInhibitorinhibitorinhibit

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