2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. DBCO-PEG3-acid

DBCO-PEG3-acid is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG3-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DBCO-PEG3-acid Chemical Structure

DBCO-PEG3-acid Chemical Structure

CAS No. : 2754384-59-1

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Based on 1 publication(s) in Google Scholar

DBCO-PEG3-acid Related Antibodies

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Description

DBCO-PEG3-acid is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG3-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups[1].

IC50 & Target[1]

Non-cleavable Linker

 

Molecular Weight

508.56

Formula

C28H32N2O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC(CCOCCOCCOCCNC(CCC(N(C1)C2=C(C=CC=C2)C#CC3=C1C=CC=C3)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (196.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9663 mL 9.8317 mL 19.6634 mL
5 mM 0.3933 mL 1.9663 mL 3.9327 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9663 mL 9.8317 mL 19.6634 mL 49.1584 mL
5 mM 0.3933 mL 1.9663 mL 3.9327 mL 9.8317 mL
10 mM 0.1966 mL 0.9832 mL 1.9663 mL 4.9158 mL
15 mM 0.1311 mL 0.6554 mL 1.3109 mL 3.2772 mL
20 mM 0.0983 mL 0.4916 mL 0.9832 mL 2.4579 mL
25 mM 0.0787 mL 0.3933 mL 0.7865 mL 1.9663 mL
30 mM 0.0655 mL 0.3277 mL 0.6554 mL 1.6386 mL
40 mM 0.0492 mL 0.2458 mL 0.4916 mL 1.2290 mL
50 mM 0.0393 mL 0.1966 mL 0.3933 mL 0.9832 mL
60 mM 0.0328 mL 0.1639 mL 0.3277 mL 0.8193 mL
80 mM 0.0246 mL 0.1229 mL 0.2458 mL 0.6145 mL
100 mM 0.0197 mL 0.0983 mL 0.1966 mL 0.4916 mL
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DBCO-PEG3-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBCO-PEG3-acid2754384-59-1ADC LinkerAntibody-drug conjugates linkerADC linker non-cleavableDBCOalkyne-azideInhibitorinhibitorinhibit

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