2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. DBCO-PEG4-VA-PBD

DBCO-PEG4-VA-PBD is a agent-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via DBCO-PEG4-VA. DBCO-PEG4-VA-PBD is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

DBCO-PEG4-VA-PBD Chemical Structure

DBCO-PEG4-VA-PBD Chemical Structure

CAS No. : 2241644-09-5

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1 mg USD 1900 In-stock
5 mg USD 3800 In-stock
10 mg USD 5600 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

DBCO-PEG4-VA-PBD Related Antibodies

Top Publications Citing Use of Products

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DBCO-PEG4-VA-PBD is a agent-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via DBCO-PEG4-VA[1]. DBCO-PEG4-VA-PBD is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

Traditional Cytotoxic Agents

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-PEG4-VA-PBD Related Antibodies
Molecular Weight

1430.60

Formula

C80H87N9O16
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

[H][C@]12N(C(C3=CC(OC)=C(OCCCOC4=C(C=C5C(N=C[C@@]6([H])N(C=C(C7=CC=C(OC)C=C7)C6)C5=O)=C4)OC)C=C3N=C2)=O)C=C(C8=CC=C(NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(CCC(N9C%10=CC=CC=C%10C#CC%11=CC=CC=C%11C9)=O)=O)=O)=O)=O)C=C8)C1
Shipping

Shipping with dry ice.
Storage

-80°C, stored under nitrogen
Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (83.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6990 mL 3.4950 mL 6.9901 mL
5 mM 0.1398 mL 0.6990 mL 1.3980 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.68% ee.: 98.95%

SDS (251 KB)

COA (251 KB) HNMR (176 KB) RP-HPLC (248 KB) NP-HPLC (284 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6990 mL 3.4950 mL 6.9901 mL 17.4752 mL
5 mM 0.1398 mL 0.6990 mL 1.3980 mL 3.4950 mL
10 mM 0.0699 mL 0.3495 mL 0.6990 mL 1.7475 mL
15 mM 0.0466 mL 0.2330 mL 0.4660 mL 1.1650 mL
20 mM 0.0350 mL 0.1748 mL 0.3495 mL 0.8738 mL
25 mM 0.0280 mL 0.1398 mL 0.2796 mL 0.6990 mL
30 mM 0.0233 mL 0.1165 mL 0.2330 mL 0.5825 mL
40 mM 0.0175 mL 0.0874 mL 0.1748 mL 0.4369 mL
50 mM 0.0140 mL 0.0699 mL 0.1398 mL 0.3495 mL
60 mM 0.0117 mL 0.0583 mL 0.1165 mL 0.2913 mL
80 mM 0.0087 mL 0.0437 mL 0.0874 mL 0.2184 mL
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DBCO-PEG4-VA-PBD Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBCO-PEG4-VA-PBD2241644-09-5Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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