2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. DBCO-Sulfo-NHS ester sodium

DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-Sulfo-NHS ester (sodium) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DBCO-Sulfo-NHS ester sodium Chemical Structure

DBCO-Sulfo-NHS ester sodium Chemical Structure

CAS No. : 1400191-52-7

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Based on 1 publication(s) in Google Scholar

DBCO-Sulfo-NHS ester sodium Related Antibodies

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Description

DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-Sulfo-NHS ester (sodium) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target[1]

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-Sulfo-NHS ester sodium Related Antibodies
Molecular Weight

532.50

Formula

C25H21N2NaO8S
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCCCC(N2C3=CC=CC=C3C#CC4=CC=CC=C4C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (93.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8779 mL 9.3897 mL 18.7793 mL
5 mM 0.3756 mL 1.8779 mL 3.7559 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 97.98%

SDS (393 KB)

COA (250 KB) HNMR (128 KB) RP-HPLC (231 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8779 mL 9.3897 mL 18.7793 mL 46.9484 mL
5 mM 0.3756 mL 1.8779 mL 3.7559 mL 9.3897 mL
10 mM 0.1878 mL 0.9390 mL 1.8779 mL 4.6948 mL
15 mM 0.1252 mL 0.6260 mL 1.2520 mL 3.1299 mL
20 mM 0.0939 mL 0.4695 mL 0.9390 mL 2.3474 mL
25 mM 0.0751 mL 0.3756 mL 0.7512 mL 1.8779 mL
30 mM 0.0626 mL 0.3130 mL 0.6260 mL 1.5649 mL
40 mM 0.0469 mL 0.2347 mL 0.4695 mL 1.1737 mL
50 mM 0.0376 mL 0.1878 mL 0.3756 mL 0.9390 mL
60 mM 0.0313 mL 0.1565 mL 0.3130 mL 0.7825 mL
80 mM 0.0235 mL 0.1174 mL 0.2347 mL 0.5869 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DBCO-Sulfo-NHS ester sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBCO-Sulfo-NHS ester1400191-52-7ADC LinkerAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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