DBCO-Val-Cit-PABC-PNP

Name: DBCO-Val-Cit-PABC-PNP
Brand: MedChemExpress
SKU: HY-130937
Rating: 4.5 (1 reviews)

Cat. No.: HY-130937 Purity: 96.54%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DBCO-Val-Cit-PABC-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-Val-Cit-PABC-PNP is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

DBCO-Val-Cit-PABC-PNP Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1280	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2100	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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View All Isoforms

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Biological Activity
Purity & Documentation
References
Customer Review

Description

DBCO-Val-Cit-PABC-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. DBCO-Val-Cit-PABC-PNP is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

Protease Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

859.92

Formula

C₄₆H₄₉N₇O₁₀

Appearance

Solid

Color

White to off-white

SMILES

CC([C@@H](C(N[C@H](C(NC1=CC=C(C=C1)COC(OC2=CC=C(C=C2)[N+]([O-])=O)=O)=O)CCCNC(N)=O)=O)NC(CCCCC(N3CC4=C(C#CC5=C3C=CC=C5)C=CC=C4)=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (116.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1629 mL	5.8145 mL	11.6290 mL
5 mM	0.2326 mL	1.1629 mL	2.3258 mL
10 mM	0.1163 mL	0.5814 mL	1.1629 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.54%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (251 KB) HNMR (486 KB) LCMS (147 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1629 mL	5.8145 mL	11.6290 mL	29.0725 mL
	5 mM	0.2326 mL	1.1629 mL	2.3258 mL	5.8145 mL
	10 mM	0.1163 mL	0.5814 mL	1.1629 mL	2.9072 mL
	15 mM	0.0775 mL	0.3876 mL	0.7753 mL	1.9382 mL
	20 mM	0.0581 mL	0.2907 mL	0.5814 mL	1.4536 mL
	25 mM	0.0465 mL	0.2326 mL	0.4652 mL	1.1629 mL
	30 mM	0.0388 mL	0.1938 mL	0.3876 mL	0.9691 mL
	40 mM	0.0291 mL	0.1454 mL	0.2907 mL	0.7268 mL
	50 mM	0.0233 mL	0.1163 mL	0.2326 mL	0.5814 mL
	60 mM	0.0194 mL	0.0969 mL	0.1938 mL	0.4845 mL
	80 mM	0.0145 mL	0.0727 mL	0.1454 mL	0.3634 mL
	100 mM	0.0116 mL	0.0581 mL	0.1163 mL	0.2907 mL