DDO-2093 dihydrochloride

Name: DDO-2093 dihydrochloride
Brand: MedChemExpress
SKU: HY-132233A
Rating: 4.5 (1 reviews)

Cat. No.: HY-132233A Purity: 98.52%: FAQs
Data Sheet SDS COA Handling Instructions

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DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC₅₀=8.6 nM; K_d=11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex.

For research use only. We do not sell to patients.

DDO-2093 dihydrochloride Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 232	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2250	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 3600	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 5800	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of DDO-2093 dihydrochloride:

DDO-2093 Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

DDO-2093 (5 μM; pretreated 7 days) dihydrochloride inhibits MLL-fusion protein dependent genes expression (HOXA9 and Meis1)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	MV4-11 cells
Concentration:	1, 2.5, 5, and 10 μM
Incubation Time:	7 days
Result:	Dose-dependently reduced the mono-, di-, and trimethylation of H3K4.

In Vivo

DDO-2093 (20-80 mg/kg; i.p.; every other day for 21 days) dihydrochloride significantly suppresses the tumor size and weight in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female nude mice (MV4-11 human leukemia cancer xenografts)^[1]
Dosage:	20, 40, and 80 mg/kg
Administration:	Intraperitoneal injection; every other day for 21 days
Result:	Had the tumor volume growth inhibition (GI) values were calculated to be 13.7%, 37.6% and 63.9% with doses of 20 mg/kg, 40 mg/kg and 80 mg/kg, respectively.

Molecular Weight

687.04

Formula

C₂₉H₃₉Cl₃FN₉O₃

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CN(C2=CC=C(N3CCN(C)CC3)C(NC(C4=CC(N)=C(F)C(C)=C4Cl)=O)=C2)N=N1)NCCCN5CCOCC5.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (145.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4555 mL	7.2776 mL	14.5552 mL
5 mM	0.2911 mL	1.4555 mL	2.9110 mL
10 mM	0.1456 mL	0.7278 mL	1.4555 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.52%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (252 KB) HNMR (219 KB) RP-HPLC (147 KB) LCMS (379 KB)

Handling Instructions (2659 KB)

References

[1]. Chen W, et al. Discovery of a potent MLL1 and WDR5 protein-protein interaction inhibitor with in vivo antitumor activity [published online ahead of print, 2021 Jun 28]. Eur J Med Chem. 2021;223:113677. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4555 mL	7.2776 mL	14.5552 mL	36.3880 mL
	5 mM	0.2911 mL	1.4555 mL	2.9110 mL	7.2776 mL
	10 mM	0.1456 mL	0.7278 mL	1.4555 mL	3.6388 mL
	15 mM	0.0970 mL	0.4852 mL	0.9703 mL	2.4259 mL
	20 mM	0.0728 mL	0.3639 mL	0.7278 mL	1.8194 mL
	25 mM	0.0582 mL	0.2911 mL	0.5822 mL	1.4555 mL
	30 mM	0.0485 mL	0.2426 mL	0.4852 mL	1.2129 mL
	40 mM	0.0364 mL	0.1819 mL	0.3639 mL	0.9097 mL
	50 mM	0.0291 mL	0.1456 mL	0.2911 mL	0.7278 mL
	60 mM	0.0243 mL	0.1213 mL	0.2426 mL	0.6065 mL
	80 mM	0.0182 mL	0.0910 mL	0.1819 mL	0.4548 mL
	100 mM	0.0146 mL	0.0728 mL	0.1456 mL	0.3639 mL