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Deiodoamiodarone  (Synonyms: L 3937; Dideiodo Amiodarone)

Cat. No.: HY-114928 Purity: ≥96.0%
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Deiodoamiodarone (L 3937; Dideiodo Amiodarone) is an intermediate of amiodarone. Amiodarone is a potent calmodulin antagonist.

For research use only. We do not sell to patients.

Deiodoamiodarone Chemical Structure

Deiodoamiodarone Chemical Structure

CAS No. : 23551-25-9

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5 mg USD 106 In-stock
10 mg USD 170 In-stock
25 mg USD 340 In-stock
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Based on 1 publication(s) in Google Scholar

Deiodoamiodarone Related Antibodies

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Description

Deiodoamiodarone (L 3937; Dideiodo Amiodarone) is an intermediate of amiodarone. Amiodarone is a potent calmodulin antagonist[1].

Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
2.77 μM
Compound: 33m
Antiproliferative activity against human HL-60 cells measured after 24 hrs by MTT assay
Antiproliferative activity against human HL-60 cells measured after 24 hrs by MTT assay
[PMID: 34605238]
MCF7 IC50
5.26 μM
Compound: 33m
Antiproliferative activity against human MCF7 cells measured after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 24 hrs by MTT assay
[PMID: 34605238]
MDA-MB-231 IC50
19.4 μM
Compound: 33m
Antiproliferative activity against human MDA-MB-231 cells measured after 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells measured after 24 hrs by MTT assay
[PMID: 34605238]
U-937 IC50
3.47 μM
Compound: 33m
Antiproliferative activity against human U-937 cells measured after 24 hrs by MTT assay
Antiproliferative activity against human U-937 cells measured after 24 hrs by MTT assay
[PMID: 34605238]
Molecular Weight

393.52

Formula

C25H31NO3
CAS No.
Appearance

Liquid (Density: 1.08 g/cm3)

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C(C=C1)OCCN(CC)CC)C2=C(OC3=CC=CC=C23)CCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (254.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5412 mL 12.7058 mL 25.4117 mL
5 mM 0.5082 mL 2.5412 mL 5.0823 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5412 mL 12.7058 mL 25.4117 mL 63.5292 mL
5 mM 0.5082 mL 2.5412 mL 5.0823 mL 12.7058 mL
10 mM 0.2541 mL 1.2706 mL 2.5412 mL 6.3529 mL
15 mM 0.1694 mL 0.8471 mL 1.6941 mL 4.2353 mL
20 mM 0.1271 mL 0.6353 mL 1.2706 mL 3.1765 mL
25 mM 0.1016 mL 0.5082 mL 1.0165 mL 2.5412 mL
30 mM 0.0847 mL 0.4235 mL 0.8471 mL 2.1176 mL
40 mM 0.0635 mL 0.3176 mL 0.6353 mL 1.5882 mL
50 mM 0.0508 mL 0.2541 mL 0.5082 mL 1.2706 mL
60 mM 0.0424 mL 0.2118 mL 0.4235 mL 1.0588 mL
80 mM 0.0318 mL 0.1588 mL 0.3176 mL 0.7941 mL
100 mM 0.0254 mL 0.1271 mL 0.2541 mL 0.6353 mL
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Deiodoamiodarone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deiodoamiodarone23551-25-9L 3937 Dideiodo AmiodaroneL3937L-3937OthersInhibitorinhibitorinhibit

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