Deoxycholic acid sodium hydrate (Synonyms: Cholanoic Acid sodium hydrate; Desoxycholic acid sodium hydrate)

Cat. No.: HY-N0593B: FAQs
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Deoxycholic acid (cholanoic acid) sodium hydrate, a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5.

For research use only. We do not sell to patients.

Deoxycholic acid sodium hydrate Chemical Structure

CAS No. : 145224-92-6

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Other In-stock Forms of Deoxycholic acid sodium hydrate:

Deoxycholic acid Deoxycholic acid sodium salt

Other Forms of Deoxycholic acid sodium hydrate:

11 Publications Citing Use of MCE Deoxycholic acid sodium hydrate

: Deoxycholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2019 Jan 31;19:24. [Abstract]; The expression of CDX2, KLF4, HNF4α, and cadherin 17 is increased upon stimulation with DCA in a dose-dependent manner.

: Deoxycholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2019 Jan 31;19:24. [Abstract]; Western blotting results indicated that the inhibition of SOX2 in bile acid-treated AGS cells is partially rescued in miR-21 knockdown AGS cells.

: Deoxycholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2019 Jan 31;19:24. [Abstract]; The expression of CDX2, KLF4, HNF4α, and cadherin 17 is increased upon stimulation with DCA in a dose-dependent manner.

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Description

Deoxycholic acid (cholanoic acid) sodium hydrate, a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5^[1]^[2].

IC₅₀ & Target

Microbial Metabolite

In Vitro

Deoxycholic acid sodium hydrate (DCA) (100 μM) induces the production of gastric cancer cell line MGC803 resistant to acidified bile acids and enhances their survival and proliferation activity under bile acid stress^[2].
Deoxycholic acid sodium hydrate (DCA) (100 μM)-induced resistant cells shows altered morphology, significantly elevated telomerase activity, better cell viability and reduces apoptosis compared to normal MGC803 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

432.57

Formula

C₂₄H₄₁NaO₅

CAS No.

145224-92-6

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O[Na])=O)([H])[C@@]3([H])[C@@](C[C@@H]1O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809. [Content Brief]

[2]. Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797. [Content Brief]

Deoxycholic acid sodium hydrate Related Classifications

Metabolic Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deoxycholic acid sodium145224-92-6Cholanoic Acid sodiumDesoxycholic acid sodiumEndogenous MetaboliteG protein-coupled Bile Acid Receptor 1G-protein coupled receptor 19GPCR19TGR5GPBAR1bile acidG protein-coupled bile acid receptorInhibitorinhibitorinhibit

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