Deoxycholic acid-d₄

Name: Deoxycholic acid-d 4
Brand: MedChemExpress
SKU: HY-N0593S
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0593S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Deoxycholic acid-d₄ is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

For research use only. We do not sell to patients.

Deoxycholic acid-d<sub>4</sub> Chemical Structure

Deoxycholic acid-d₄ Chemical Structure

CAS No. : 112076-61-6

Size	Price	Stock	Quantity
1 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Deoxycholic acid-d₄:

Deoxycholic acid In-stock
Deoxycholic acid sodium salt In-stock
Deoxycholic acid sodium hydrate Get quote
Deoxycholic acid-d₅ Get quote
Deoxycholic acid-d₆ Get quote
Deoxycholic acid-¹³C Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.60

Formula

C₂₄H₃₆D₄O₄

CAS No.

112076-61-6

Unlabeled CAS

83-44-3

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1C([2H])(C[C@]2([C@@]([H])(C1([2H])[2H])CC[C@@]3([C@@]2(C[C@@H]([C@]4([C@]3(CC[C@@]4([C@@H](CCC(O)=O)C)[H])[H])C)O)[H])[H])C)[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (252.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5214 mL	12.6072 mL	25.2143 mL
5 mM	0.5043 mL	2.5214 mL	5.0429 mL
10 mM	0.2521 mL	1.2607 mL	2.5214 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (274 KB) SDS (392 KB)

COA (252 KB) HNMR (270 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809. [Content Brief]

[3]. Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	2.5214 mL	12.6072 mL	25.2143 mL	63.0358 mL
	5 mM	0.5043 mL	2.5214 mL	5.0429 mL	12.6072 mL
	10 mM	0.2521 mL	1.2607 mL	2.5214 mL	6.3036 mL
	15 mM	0.1681 mL	0.8405 mL	1.6810 mL	4.2024 mL
	20 mM	0.1261 mL	0.6304 mL	1.2607 mL	3.1518 mL
	25 mM	0.1009 mL	0.5043 mL	1.0086 mL	2.5214 mL
	30 mM	0.0840 mL	0.4202 mL	0.8405 mL	2.1012 mL
	40 mM	0.0630 mL	0.3152 mL	0.6304 mL	1.5759 mL
	50 mM	0.0504 mL	0.2521 mL	0.5043 mL	1.2607 mL
	60 mM	0.0420 mL	0.2101 mL	0.4202 mL	1.0506 mL
	80 mM	0.0315 mL	0.1576 mL	0.3152 mL	0.7879 mL
	100 mM	0.0252 mL	0.1261 mL	0.2521 mL	0.6304 mL