Desipramine

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Desipramine is a tricyclic psychotic compound, possessing antidepressant activity. Desipramine inhibits the norepinephrine reuptake receptor in the central nervous system and reduces the sleep-related loss of genioglossus activity, can be used to research the improvement of pharyngeal collapsibility.

For research use only. We do not sell to patients.

Desipramine Chemical Structure

CAS No. : 50-47-5

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Other In-stock Forms of Desipramine:

Desipramine hydrochloride

Other Forms of Desipramine:

11 Publications Citing Use of MCE Desipramine

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

Norepinephrine Reuptake Receptor^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
DG-75	IC₅₀	39.81 μM Compound: Desipramine	Reduction in cell viability of human DG75 cells after 24 hrs by Alamar blue viability assay Reduction in cell viability of human DG75 cells after 24 hrs by Alamar blue viability assay	[PMID: 23385211]
HEK293	IC₅₀	1520 nM Compound: Desipramine	Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA	[PMID: 21300721]
HEK293	IC₅₀	56.8 μM Compound: desipramine	Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy	[PMID: 18788725]
HEK293	IC₅₀	9.18 μM Compound: Desipramine	Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay	[PMID: 28230985]
HeLa	IC₅₀	17.78 μM Compound: Desipramine	Reduction in cell viability of human HeLa cells after 24 hrs by Alamar blue viability assay Reduction in cell viability of human HeLa cells after 24 hrs by Alamar blue viability assay	[PMID: 23385211]
MDCK	IC₅₀	0.93 nM Compound: desipramine	Displacement of [125I]RTI55 from human recombinant norepinephrine transporter expressed in MDCK cells after 3 hrs Displacement of [125I]RTI55 from human recombinant norepinephrine transporter expressed in MDCK cells after 3 hrs	[PMID: 23403082]
Splenocyte	IC₅₀	22.9 μM Compound: Desipramine	Cytotoxicity against C57BL/6J mouse splenocytes after 72 hrs by alamar blue assay Cytotoxicity against C57BL/6J mouse splenocytes after 72 hrs by alamar blue assay	[PMID: 17846138]
Ventricular myocyte	IC₅₀	1.709 μM Compound: Desipramine	Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes	[PMID: 22761000]
Ventricular myocyte	IC₅₀	11.7 μM Compound: Desipramine	Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes	[PMID: 22761000]
Ventricular myocyte	IC₅₀	1709 nM Compound: Desipramine	Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes	[PMID: 21300721]

Clinical Trial

Molecular Weight

266.38

Formula

C₁₈H₂₂N₂

CAS No.

50-47-5

SMILES

CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Garcia AS, et al. Autoreceptor-mediated inhibition of norepinephrine release in rat medial prefrontal cortex is maintained after chronic desipramine treatment. J Neurochem. 2004 Nov;91(3):683-93. [Content Brief]

[2]. Taranto-Montemurro L, et al. Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation. Eur Respir J. 2016 Nov;48(5):1340-1350. [Content Brief]

Desipramine Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desipramine50-47-5Adrenergic ReceptorBeta ReceptorantidepressantnorepinephrinegenioglossuspharyngealInhibitorinhibitorinhibit

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