Desmosterol-d₆

Name: Desmosterol-d 6
Brand: MedChemExpress
SKU: HY-113224S
Rating: 4.5 (1 reviews)

Cat. No.: HY-113224S: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Desmosterol-d₆ is the deuterium labeled Desmosterol. Desmosterol is a molecule similar to cholesterol. Desmosterol is the immediate precursor of cholesterol in the Bloch pathway of cholesterol biosynthesis. Desmosterol, as an endogenous metabolite, used to study cholesterol metabolism[1].

For research use only. We do not sell to patients.

Desmosterol-d<sub>6</sub> Chemical Structure

Desmosterol-d₆ Chemical Structure

CAS No. : 1246298-67-8

Size	Price	Stock	Quantity
500 μg	USD 253	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 406	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Desmosterol-d₆:

Desmosterol Get quote

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Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

390.67

Formula

C₂₇H₃₈D₆O

CAS No.

1246298-67-8

Unlabeled CAS

313-04-2

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC/C=C(C([2H])([2H])[2H])/C([2H])([2H])[2H])([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : ≥ 50 mg/mL (127.99 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5597 mL	12.7985 mL	25.5971 mL
5 mM	0.5119 mL	2.5597 mL	5.1194 mL
10 mM	0.2560 mL	1.2799 mL	2.5597 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Clark RM, et al. Desmosterol in human milk. Lipids. 1983;18(3):264-266. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF	1 mM	2.5597 mL	12.7985 mL	25.5971 mL	63.9926 mL
	5 mM	0.5119 mL	2.5597 mL	5.1194 mL	12.7985 mL
	10 mM	0.2560 mL	1.2799 mL	2.5597 mL	6.3993 mL
	15 mM	0.1706 mL	0.8532 mL	1.7065 mL	4.2662 mL
	20 mM	0.1280 mL	0.6399 mL	1.2799 mL	3.1996 mL
	25 mM	0.1024 mL	0.5119 mL	1.0239 mL	2.5597 mL
	30 mM	0.0853 mL	0.4266 mL	0.8532 mL	2.1331 mL
	40 mM	0.0640 mL	0.3200 mL	0.6399 mL	1.5998 mL
	50 mM	0.0512 mL	0.2560 mL	0.5119 mL	1.2799 mL
	60 mM	0.0427 mL	0.2133 mL	0.4266 mL	1.0665 mL
	80 mM	0.0320 mL	0.1600 mL	0.3200 mL	0.7999 mL
	100 mM	0.0256 mL	0.1280 mL	0.2560 mL	0.6399 mL