Dexamethasone-4,6α,21,21-d₄

Name: Dexamethasone-4,6α,21,21-d 4
Brand: MedChemExpress
SKU: HY-14648S3
Rating: 4.5 (1 reviews)

Cat. No.: HY-14648S3 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Dexamethasone-4,6α,21,21-d₄ is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

For research use only. We do not sell to patients.

Dexamethasone-4,6α,21,21-d<sub>4</sub> Chemical Structure

Dexamethasone-4,6α,21,21-d₄ Chemical Structure

CAS No. : 2483831-63-4

Size	Price	Stock	Quantity
500 μg	USD 158	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Dexamethasone-4,6α,21,21-d₄:

Dexamethasone In-stock
Dexamethasone-d₃-1 Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

View All Isoforms

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.49

Formula

C₂₂H₂₅D₄FO₅

CAS No.

2483831-63-4

Unlabeled CAS

50-02-2

Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@]4(C)[C@](C(C([2H])([2H])O)=O)(O)[C@H](C)C[C@@]4([H])[C@]3([H])C[C@H]([2H])C2=C1[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 30 mg/mL (75.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5221 mL	12.6107 mL	25.2213 mL
5 mM	0.5044 mL	2.5221 mL	5.0443 mL
10 mM	0.2522 mL	1.2611 mL	2.5221 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (282 KB) SDS (419 KB)

COA (261 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22. [Content Brief]

[3]. Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11 [Content Brief]

[4]. Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56 [Content Brief]

[5]. Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9. [Content Brief]

[6]. Ballabh P, et al. Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids. Arch Dis Child Fetal Neonatal Ed. 2004 Jan;89(1):F76-83. [Content Brief]

[7]. Heidi Ledford. et al. Coronavirus Breakthrough: Dexamethasone Is First Drug Shown to Save Lives. Nature. 2020 Jun 16. [Content Brief]

[8]. Yun Chen, et al. Glucocorticoids inhibit production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Int J Clin Exp Pathol 2018;11(7):3391-3397.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5221 mL	12.6107 mL	25.2213 mL	63.0533 mL
	5 mM	0.5044 mL	2.5221 mL	5.0443 mL	12.6107 mL
	10 mM	0.2522 mL	1.2611 mL	2.5221 mL	6.3053 mL
	15 mM	0.1681 mL	0.8407 mL	1.6814 mL	4.2036 mL
	20 mM	0.1261 mL	0.6305 mL	1.2611 mL	3.1527 mL
	25 mM	0.1009 mL	0.5044 mL	1.0089 mL	2.5221 mL
	30 mM	0.0841 mL	0.4204 mL	0.8407 mL	2.1018 mL
	40 mM	0.0631 mL	0.3153 mL	0.6305 mL	1.5763 mL
	50 mM	0.0504 mL	0.2522 mL	0.5044 mL	1.2611 mL
	60 mM	0.0420 mL	0.2102 mL	0.4204 mL	1.0509 mL