Dexamethasone  (Synonyms: Hexadecadrol; Prednisolone F)

Dexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor^[1][2][3][4].

Dexamethasone (GMP) (100 nM; 10 d) increases myotubes formation and cytoplasmic lipid droplets accumulation of RCJ 3.1 cells^[1].
Dexamethasone (GMP) (10 nM-1 μM; 0-6 d) induces osteogenesis of chick periosteum cells with an optimal concentration of 100 nM^[2].
Dexamethasone (GMP) (10 μM) induces osteoblastic differentiation^[3].
Dexamethasone (GMP) (10 nM) stimulates differentiation of odontoblast-like cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

392.46

C₂₂H₂₉FO₅

50-02-2

Solid

White to off-white

O=C1C=C[C@]2(C(CC[C@@]3([C@@]2([C@H](C[C@]4([C@]3(C[C@H]([C@]4(O)C(CO)=O)C)[H])C)O)F)[H])=C1)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Grigoriadis AE, et al. Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone. J Cell Biol. 1988 Jun;106(6):2139-51.  [Content Brief]

  [2]. Tenenbaum HC, Heersche JN. Dexamethasone stimulates osteogenesis in chick periosteum in vitro. Endocrinology. 1985 Nov;117(5):2211-7.  [Content Brief]

  [3]. Rickard DJ, et al. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev Biol. 1994 Jan;161(1):218-28.  [Content Brief]

  [4]. Alliot-Licht B, et al. Dexamethasone stimulates differentiation of odontoblast-like cells in human dental pulp cultures. Cell Tissue Res. 2005 Sep;321(3):391-400.  [Content Brief]