Dexamethasone (Synonyms: Hexadecadrol; Prednisolone F)

Cat. No.: HY-14648G: FAQs
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Dexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor.

For research use only. We do not sell to patients.

Dexamethasone Chemical Structure

CAS No. : 50-02-2

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Dexamethasone

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140 Publications Citing Use of MCE Dexamethasone

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RT-PCR

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 1 January 2023, 120179.; Immunofluorescence analysis of Itgb2 in Dexamethasone (100 nM; for 1 hour)-treated MODE-K cells.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 1 January 2023, 120179.; mRNA levels of Itgb2 in Dexamethasone (100 nM; for 1 hour)-treated MODE-K cells.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 1 January 2023, 120179.; Western blotting analysis of Itgb2 levels in Dexamethasone (100 nM; for 1 hour)-treated MODE-K cells.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2017-2030. [Abstract]; qRT‐PCR results show that DEX (DEX; 25 μg/g ; once a day; for 10 days)-induced myotube atrophy can increase the expression levels of MuRF1, Atrogin‐1, FoxO3a, SYISL, and miR‐205‐5p, decrease the expression levels of miR‐23a‐3p and miR‐103‐3p, but does not affect the expression level of SYNPO2.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2017-2030. [Abstract]; Western blotting results show that SYISL overexpression can further promote protein ubiquitination levels in Dexamethasone (DEX; 25 μg/g ; once a day; for 10 days)-induced muscular atrophy. Muscle atrophy is induced by intraperitoneal injection of DEX for 10 days in 3‐month‐old wild‐type and KO mice, respectively.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2017-2030. [Abstract]; Representative photographs of H&E and Lamin immunofluorescence staining for WT and KO TA muscles. Quantification of five independent experiments shows that knockout of SYISL alleviates muscle weight loss caused by Dexamethasone (DEX; 25 μg/g ; once a day; for 10 days)-induced muscle atrophy.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Oncogene. 2021 Sep;40(35):5367-5378. [Abstract]; 4T1 cells are treated with Dexamethasone (Dex; 100 nM)/GSK650394 in vitro for 48 h before inoculation via intravenous injection.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Oncogene. 2021 Sep;40(35):5367-5378. [Abstract]; For in situ treatment in the 4T1 tumor model, Dexamethasone (Dex; 3 mg/kg) is performed every three days by gavage twice/day. The expression of Nedd4l, p-Nedd4l, Smad2 and p-Smad2 after SGK1 knockout.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Oncogene. 2021 Sep;40(35):5367-5378. [Abstract]; The GR expression of 4T1 cells treated with Dexamethasone (100 nM)/Mifepristone for 48 h.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Oncogene. 2021 Sep;40(35):5367-5378. [Abstract]; The migration assay of 4T1 cells in different condition. 4T1 cells were pretreated with 100 nM Dexamethasone (Dex) for 48 h and then are used for Transwell.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Aug;178(15):2976-2997. [Abstract]; Primary microglial cells incubated with Protopanaxadiol (100 μM), Dexamethasone (100 nM) or Dexamethasone-BSA (10 nM) show remarkable dynorphin A expression. Pretreatment with Dexamethasone-21-mesylate for 0.5 h completely abolished Protopanaxadiol-, Dexamethasone- or Dexamethasone-BSA-stimulated dynorphin A expression.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Biomaterials. 2020 Feb;232:119730. [Abstract]; Raw264.7 cells are treated with various concentrations of blank NPs, free Dexamethasone (Dex), Dex/Oxi-αCD NPs, or Dex/FA-Oxi-αCD NPs for 24 h, the optical density values at 450 nm were measured and the cell viability was determined by CCK-8 assay.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Biomaterials. 2020 Feb;232:119730. [Abstract]; Raw264.7 cells are treated with various concentrations of blank NPs, free Dexamethasone (Dex), Dex/Oxi-αCD NPs, or Dex/FA-Oxi-αCD NPs for 24 h, mRNA level of iRhom2 in Raw264.7 cells is detected by quantitative real-time PCR. Data are presented by the relative amount of mRNA normalized by GAPDH.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Biomaterials. 2020 Feb;232:119730. [Abstract]; Raw264.7 macrophages induced with LPS (1 μg/mL) for 6 h. Then cellular uptake of Cy5-labeled Dexamethasone (Dex)/OxiαCD NPs or Dex/FA-Oxi-αCD NPs is assessed using confocal laser scanning microscopy at various times.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Biomaterials. 2020 Feb;232:119730. [Abstract]; Western blot analysis of iRhom2, TNF-α, and BAFF expression in Raw264.7 cells treated with various concentrations of blank NPs, free Dexamethasone (Dex), Dex/Oxi-αCD NPs, or Dex/FA-Oxi-αCD NPs for 24 h.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2020 Oct;180:114145. [Abstract]; Translocation of FoxO3 after treatment with S-Rg3 in DEX-treated C2C12 myotubes was investigated by immunofluorescence staining.

: Dexamethasone purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2020 Oct;180:114145. [Abstract]; After C2C12 myotubes are incubated with Dexamethasone (DEX) and S-Rg3 for 24 h, myotube levels of MuRF1 and atrogin-1 are detected using Western blot analysis.

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References
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Description

In Vitro

Dexamethasone (GMP) (100 nM; 10 d) increases myotubes formation and cytoplasmic lipid droplets accumulation of RCJ 3.1 cells^[1].
Dexamethasone (GMP) (10 nM-1 μM; 0-6 d) induces osteogenesis of chick periosteum cells with an optimal concentration of 100 nM^[2].
Dexamethasone (GMP) (10 μM) induces osteoblastic differentiation^[3].
Dexamethasone (GMP) (10 nM) stimulates differentiation of odontoblast-like cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

392.46

Formula

C₂₂H₂₉FO₅

CAS No.

50-02-2

SMILES

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@@]4(C(CO)=O)O)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Grigoriadis AE, et al. Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone. J Cell Biol. 1988 Jun;106(6):2139-51. [Content Brief]

[2]. Tenenbaum HC, Heersche JN. Dexamethasone stimulates osteogenesis in chick periosteum in vitro. Endocrinology. 1985 Nov;117(5):2211-7. [Content Brief]

[3]. Rickard DJ, et al. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev Biol. 1994 Jan;161(1):218-28. [Content Brief]

[4]. Alliot-Licht B, et al. Dexamethasone stimulates differentiation of odontoblast-like cells in human dental pulp cultures. Cell Tissue Res. 2005 Sep;321(3):391-400. [Content Brief]

Dexamethasone Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dexamethasone (GMP)50-02-2Hexadecadrol (GMP) Prednisolone F (GMP)Glucocorticoid ReceptorADC CytotoxinADC PayloadGMPmyotubeslipid dropletsosteogenesisosteoblastic differentiationInhibitorinhibitorinhibit

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