2. Neuronal Signaling
  3. Serotonin Transporter
  4. Dextromilnacipran

Dextromilnacipran  (Synonyms: (1R,2S)-milnacipran; F2696)

Cat. No.: HY-14794 Purity: 99.90%
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Dextromilnacipran (F2696; (1R,2S)-milnacipran), an enantiomer of milnacipran, is a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. Dextromilnacipran also is a human alpha-adrenergic receptor antagonist, with an IC50 of 3.4 μM. (patent WO2013014263A1).

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Dextromilnacipran Chemical Structure

Dextromilnacipran Chemical Structure

CAS No. : 96847-55-1

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Based on 1 publication(s) in Google Scholar

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Description

Dextromilnacipran (F2696; (1R,2S)-milnacipran), an enantiomer of milnacipran, is a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. Dextromilnacipran also is a human alpha-adrenergic receptor antagonist, with an IC50 of 3.4 μM. (patent WO2013014263A1).

IC50 & Target

IC50: 3.4 μM (alpha-adrenergic receptor)
Molecular Weight

246.35

Formula

C15H22N2O
CAS No.
Appearance

Liquid (Density: 1.077±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C([C@@]1(C2=CC=CC=C2)[C@@H](CN)C1)N(CC)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (202.96 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0593 mL 20.2963 mL 40.5927 mL
5 mM 0.8119 mL 4.0593 mL 8.1185 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0593 mL 20.2963 mL 40.5927 mL 101.4816 mL
5 mM 0.8119 mL 4.0593 mL 8.1185 mL 20.2963 mL
10 mM 0.4059 mL 2.0296 mL 4.0593 mL 10.1482 mL
15 mM 0.2706 mL 1.3531 mL 2.7062 mL 6.7654 mL
20 mM 0.2030 mL 1.0148 mL 2.0296 mL 5.0741 mL
25 mM 0.1624 mL 0.8119 mL 1.6237 mL 4.0593 mL
30 mM 0.1353 mL 0.6765 mL 1.3531 mL 3.3827 mL
40 mM 0.1015 mL 0.5074 mL 1.0148 mL 2.5370 mL
50 mM 0.0812 mL 0.4059 mL 0.8119 mL 2.0296 mL
60 mM 0.0677 mL 0.3383 mL 0.6765 mL 1.6914 mL
80 mM 0.0507 mL 0.2537 mL 0.5074 mL 1.2685 mL
100 mM 0.0406 mL 0.2030 mL 0.4059 mL 1.0148 mL
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Dextromilnacipran Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dextromilnacipran96847-55-1(1R,2S)-milnacipran F2696F2696F 2696F-2696Serotonin Transporter5-HTTSERTSLC6A4milnacipranalpha-adrenergicantagonistInhibitorinhibitorinhibit

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