Milnacipran hydrochloride

Name: Milnacipran hydrochloride
Brand: MedChemExpress
SKU: HY-B0168A
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0168A Purity: 99.71%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for fibromyalgia.

For research use only. We do not sell to patients.

Milnacipran hydrochloride Chemical Structure

CAS No. : 101152-94-7

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Milnacipran hydrochloride:

Milnacipran ((1S-cis) hydrochloride) In-stock
Dextromilnacipran Get quote
Milnacipran-d₅ hydrochloride Get quote
Milnacipran Get quote
Milnacipran hydrochloride (Standard) Get quote

1 Publications Citing Use of MCE Milnacipran hydrochloride

•Cell Rep Med. 2023 Mar 21;4(3):100979. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for fibromyalgia.

Clinical Trial

Molecular Weight

282.81

Formula

C₁₅H₂₃ClN₂O

CAS No.

101152-94-7

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@]1(C2=CC=CC=C2)[C@@H](CN)C1)N(CC)CC.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (353.59 mM)

DMSO : ≥ 48 mg/mL (169.73 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5359 mL	17.6797 mL	35.3594 mL
5 mM	0.7072 mL	3.5359 mL	7.0719 mL
10 mM	0.3536 mL	1.7680 mL	3.5359 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 110 mg/mL (388.95 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.71%

Select Batch:

Data Sheet (275 KB) SDS (420 KB)

COA (252 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Moret C, et al. Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology. 1985 Dec;24(12):1211-9. [Content Brief]

[2]. Briley M, et al. Preclinical pharmacology of milnacipran. Int Clin Psychopharmacol. 1996 Sep;11 Suppl 4:9-14. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	3.5359 mL	17.6797 mL	35.3594 mL	88.3986 mL
	5 mM	0.7072 mL	3.5359 mL	7.0719 mL	17.6797 mL
	10 mM	0.3536 mL	1.7680 mL	3.5359 mL	8.8399 mL
	15 mM	0.2357 mL	1.1786 mL	2.3573 mL	5.8932 mL
	20 mM	0.1768 mL	0.8840 mL	1.7680 mL	4.4199 mL
	25 mM	0.1414 mL	0.7072 mL	1.4144 mL	3.5359 mL
	30 mM	0.1179 mL	0.5893 mL	1.1786 mL	2.9466 mL
	40 mM	0.0884 mL	0.4420 mL	0.8840 mL	2.2100 mL
	50 mM	0.0707 mL	0.3536 mL	0.7072 mL	1.7680 mL
	60 mM	0.0589 mL	0.2947 mL	0.5893 mL	1.4733 mL
	80 mM	0.0442 mL	0.2210 mL	0.4420 mL	1.1050 mL
	100 mM	0.0354 mL	0.1768 mL	0.3536 mL	0.8840 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.