DGN462

Cat. No.: HY-101150: FAQs
Data Sheet Handling Instructions

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DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs).

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (sulfo-DGN462 sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

DGN462 Chemical Structure

CAS No. : 1394079-41-4

Size		Stock
5 mg		Get quote	Estimated Time of Arrival: December 31
10 mg		Get quote	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

Other Forms of DGN462:

sulfo-DGN462 sodium Get quote

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Biological Activity
Purity & Documentation
References
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Description	DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs)^[1].
In Vitro	DGN462 is a member of the DNA-alkylating indolinobenzodiazepine pseudodimers (IGNs) class^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. DGN462 Related Antibodies
Molecular Weight	942.13
Formula	C₅₃H₅₉N₅O₉S
CAS No.	1394079-41-4
SMILES	O=C1N2[C@](CC3=C2C=CC=C3)([H])CNC4=CC(OCC5=CC(N(CC(C)(S)C)CCOCCOCCOC)=CC(COC6=C(OC)C=C7C(N8[C@](CC9=C8C=CC=C9)([H])C=NC7=C6)=O)=C5)=C(OC)C=C14
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639. [Content Brief]

DGN462 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DGN4621394079-41-4DGN 462DGN-462DNA Alkylator/CrosslinkerADC CytotoxinADC Payloadanti-tumoractivityacutemyeloidleukemiaAMLcytotoxiclymphomaInhibitorinhibitorinhibit

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