2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  3. DNA Alkylator/Crosslinker ADC Cytotoxin
  4. sulfo-DGN462 sodium

sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

sulfo-DGN462 sodium Chemical Structure

sulfo-DGN462 sodium Chemical Structure

CAS No. : 1401203-09-5

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Other Forms of sulfo-DGN462 sodium:

sulfo-DGN462 sodium Related Antibodies

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Description

sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML)[1].

In Vitro

DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs). DGN462 is a member of the DNA-alkylating indolinobenzodiazepine pseudodimers (IGNs) class[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

sulfo-DGN462 sodium Related Antibodies
Molecular Weight

1046.19

Formula

C53H60N5NaO12S2
CAS No.
SMILES

O=C(C1=CC(OC)=C2OCC3=CC(N(CC(C)(S)C)CCOCCOCCOC)=CC(COC(C=C(NC[C@@]4([H])N(C5=CC=CC=C5C4)C6=O)C6=C7)=C7OC)=C3)N(C8=CC=CC=C8C9)[C@]9([H])C(NC1=C2)[S](=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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sulfo-DGN462 sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

sulfo-DGN4621401203-09-5DNA Alkylator/CrosslinkerADC CytotoxinADC PayloaddegradedculturemediumplasmacytotoxicAMLmyeloidleukemiaInhibitorinhibitorinhibit

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