2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Dihydroorotate Dehydrogenase DNA/RNA Synthesis
  4. hDHODH-IN-5

DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia.

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hDHODH-IN-5 Chemical Structure

hDHODH-IN-5 Chemical Structure

CAS No. : 2029049-77-0

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Based on 1 publication(s) in Google Scholar

hDHODH-IN-5 Related Antibodies

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Description

DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia[1].

In Vitro

The lysozyme-GFPER-HoxA9 murine cell line (ER-HOX-GFP) and the THP1 and U937 human AML cell lines were cultured with compounds in a 4-day differentiation assay. DHODH-IN-7 shows EC50s of 3.6, 2.7, and 2.5 μM for ER-HOX-GFP, THP1 and U937 human AML cell lines, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

hDHODH-IN-5 Related Antibodies
Molecular Weight

390.40

Formula

C21H21F3N2O2
CAS No.
SMILES

O=C(NCCC(N[C@@H]1CCCC2=C1C=CC=C2)=O)C3=CC=C(C(F)(F)F)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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hDHODH-IN-5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hDHODH-IN-52029049-77-0Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHdifferentiation,acutemyeloidleukemiaU937cellsTHP-1Inhibitorinhibitorinhibit

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