DHQZ 36

Cat. No.: HY-123601: FAQs
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DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages with an EC₅₀ of 13.63 μM. DHQZ 36 has potent anti-parasite activity.

For research use only. We do not sell to patients.

DHQZ 36 Chemical Structure

CAS No. : 1542098-94-1

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Description	DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits *Leishmania amazonensis* infection in macrophages with an EC₅₀ of 13.63 μM. DHQZ 36 has potent anti-parasite activity^[1].
IC₅₀ & Target	EC50: 13.63 μM (Leishmania amazonensis)^[1]
In Vitro	With increasing concentrations of DHQZ 36 there is a significant diminution in the size of parasitophorous vacuoles (LPVs), vacuole sizes are reduced by 30% at 50 μM. These parasites also cause a reduction in the number of parasites per macrophage. Significant parasite loss is observed with as low as 5 μM after treatment with DHQZ 36. Parasites are unable to recover growth when treated with DHQZ 36 at concentrations at or above 12.5 μM^[1]. DHQZ 36 causes over 40% reduction in secreted of parasite proteins. DHQZ 36 causes a reversal in Leishmania induced suppression of IL-6 release by infected cells after LPS activation^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. DHQZ 36 Related Antibodies
Molecular Weight	384.44
Formula	C₂₁H₁₈F₂N₂OS
CAS No.	1542098-94-1
SMILES	O=C1N(CC2=CC=C(F)C=C2)C(C3=CC=C(CC)S3)NC4=C1C=C(F)C=C4
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (282 KB) Handling Instructions (2659 KB)
References	[1]. Craig E, et al. Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections. PLoS Negl Trop Dis. 2017 May 15;11(5):e0005556. [Content Brief]

DHQZ 36 Related Classifications

Infection

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHQZ 361542098-94-1DHQZ36DHQZ-36ParasiteLeishmaniaamazonensisparasitophorousvacuolesIL-6LPSanti-parasite InfectionInhibitorinhibitorinhibit

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