2. Immunology/Inflammation Apoptosis
  3. NO Synthase TNF Receptor
  4. DHU-Se1

DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1.

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DHU-Se1 Chemical Structure

DHU-Se1 Chemical Structure

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DHU-Se1 Related Antibodies

Top Publications Citing Use of Products

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nNOS iNOS eNOS

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1[1].

IC50 & Target

Selenium, iNOS, TNF-α[1]
In Vitro

DHU-Se1 (50 μM; 24 h) displays low biological toxicity in RAW cells[1].
DHU-Se1 (20 μM; 24 h) reduces the expression of cellular inflammatory factors[1].
DHU-Se1 (20 μM; 24 h) blocks the polarization of macrophages from M0 to M1 upon activation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DHU-Se1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: RAW cells
Concentration: 50 μM
Incubation Time: 24 h
Result: Displayed low biological toxicity with a survival rate larger than 80%.

RT-PCR[1]

Cell Line: RAW cells (co-treated with 100 ng/mL LPS)
Concentration: 20 μM
Incubation Time: 24 h
Result: Reduced the expression of TNF-α and iNOS significantly.

Western Blot Analysis[1]

Cell Line: RAW 264.7 macrophages (co-treated with 100 ng/mL LPS)
Concentration: 20 μM
Incubation Time: 24 h
Result: Significantly decreased the expression level of iNOS, indicating that M0 to M1 polarization was blocked.
Released the reactive selenium compound.
Molecular Weight

468.47

Formula

C23H23N3OSSe
SMILES

CN(C1=CC=C2C(SC3=C(N2C([Se]C4=CC=CC=C4)=O)C=CC(N(C)C)=C3)=C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DHU-Se1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHU-Se1NO SynthaseTNF ReceptorNitric oxide synthasesNOSTumor Necrosis Factor ReceptorTNFRAnti-inflammatoryRAW 264.7 macrophagesseleniumcellular inflammatory factorscell polarizationInhibitorinhibitorinhibit

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HY-151188
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