2. Membrane Transporter/Ion Channel
  3. EAAT
  4. NA-014

NA-014 (40) is a selective EAAT2 positive allosteric modulator (PAM), with an EC50 of 3 nM.

For research use only. We do not sell to patients.

NA-014 Chemical Structure

NA-014 Chemical Structure

Size Price Stock Quantity
5 mg USD 220 In-stock
10 mg USD 350 In-stock
25 mg USD 700 In-stock
50 mg USD 1120 In-stock
100 mg USD 1790 In-stock
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Based on 1 publication(s) in Google Scholar

NA-014 Related Antibodies

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EAAT1 EAAT2 EAAT3 EAAT4 EAAT5

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Description

NA-014 (40) is a selective EAAT2 positive allosteric modulator (PAM), with an EC50 of 3 nM[1].
Molecular Weight

380.46

Formula

C22H25FN4O
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(NCCC1=CC=C(F)C=C1)C(C2=CC=C(C#N)C=C2)N3CCN(C)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (328.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6284 mL 13.1420 mL 26.2840 mL
5 mM 0.5257 mL 2.6284 mL 5.2568 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6284 mL 13.1420 mL 26.2840 mL 65.7099 mL
5 mM 0.5257 mL 2.6284 mL 5.2568 mL 13.1420 mL
10 mM 0.2628 mL 1.3142 mL 2.6284 mL 6.5710 mL
15 mM 0.1752 mL 0.8761 mL 1.7523 mL 4.3807 mL
20 mM 0.1314 mL 0.6571 mL 1.3142 mL 3.2855 mL
25 mM 0.1051 mL 0.5257 mL 1.0514 mL 2.6284 mL
30 mM 0.0876 mL 0.4381 mL 0.8761 mL 2.1903 mL
40 mM 0.0657 mL 0.3285 mL 0.6571 mL 1.6427 mL
50 mM 0.0526 mL 0.2628 mL 0.5257 mL 1.3142 mL
60 mM 0.0438 mL 0.2190 mL 0.4381 mL 1.0952 mL
80 mM 0.0329 mL 0.1643 mL 0.3285 mL 0.8214 mL
100 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.6571 mL
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NA-014 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NA-014NA014NA 014EAATExcitatory amino acid transporter Glutamate transporter;Inhibitorinhibitorinhibit

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