2. Metabolic Enzyme/Protease
  3. Liposome
  4. di-Pal-MTO

di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity.

For research use only. We do not sell to patients.

di-Pal-MTO Chemical Structure

di-Pal-MTO Chemical Structure

CAS No. : 1349197-90-5

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5 mg USD 200 In-stock
10 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

di-Pal-MTO Related Antibodies

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Description

di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity[1].

In Vitro

Delivery of Mcl-1-specific anticancer siRNA (siMcl-1) using nanoparticles of mono-Pal-MTO and di-Pal-MTO (md11-Pal-MTO) in a 1:1 molar ratio enhances in vitro antitumour activity, reducing tumour cell viability by 81% and tumour size by 83%. Lipofectamine 2000-mediated transfection with siMcl-1 reduces tumour cell viability by 68%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

di-Pal-MTO Related Antibodies
Molecular Weight

917.27

Formula

C54H84N4O8
CAS No.
Appearance

Solid

Color

Dark purple to black

SMILES

CCCCCC/C=C\CCCCCCCC(OCCNCCNC1=C2C(C(C3=C(O)C=CC(O)=C3C2=O)=O)=C(C=C1)NCCNCCOC(CCCCCCC/C=C\CCCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (10.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0902 mL 5.4510 mL 10.9019 mL
5 mM 0.2180 mL 1.0902 mL 2.1804 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0902 mL 5.4510 mL 10.9019 mL 27.2548 mL
5 mM 0.2180 mL 1.0902 mL 2.1804 mL 5.4510 mL
10 mM 0.1090 mL 0.5451 mL 1.0902 mL 2.7255 mL
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di-Pal-MTO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

di-Pal-MTO1349197-90-5Liposomemitoxantronepalmitoleic acidsiRNAanticancerInhibitorinhibitorinhibit

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HY-148702
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