Dichlorophenyl-ABA

Name: Dichlorophenyl-ABA
Brand: MedChemExpress
SKU: HY-113950
Rating: 4.5 (1 reviews)

Cat. No.: HY-113950 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells.

For research use only. We do not sell to patients.

Dichlorophenyl-ABA Chemical Structure

CAS No. : 18201-65-5

Size	Price	Stock	Quantity
1 mg	USD 108	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2150	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells^[1].

IC₅₀ & Target

Transthyretin (TTR) amyloid fibril formation

In Vitro

Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are^[1].
Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

282.12

Formula

C₁₃H₉Cl₂NO₂

CAS No.

18201-65-5

Appearance

Solid

Color

White to light yellow

SMILES

O=C(O)C1=CC=CC=C1NC2=CC(Cl)=CC(Cl)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (354.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5446 mL	17.7230 mL	35.4459 mL
5 mM	0.7089 mL	3.5446 mL	7.0892 mL
10 mM	0.3545 mL	1.7723 mL	3.5446 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Cardoso I, et al. Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design. Biochem J. 2007 Nov 15;408(1):131-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5446 mL	17.7230 mL	35.4459 mL	88.6148 mL
	5 mM	0.7089 mL	3.5446 mL	7.0892 mL	17.7230 mL
	10 mM	0.3545 mL	1.7723 mL	3.5446 mL	8.8615 mL
	15 mM	0.2363 mL	1.1815 mL	2.3631 mL	5.9077 mL
	20 mM	0.1772 mL	0.8861 mL	1.7723 mL	4.4307 mL
	25 mM	0.1418 mL	0.7089 mL	1.4178 mL	3.5446 mL
	30 mM	0.1182 mL	0.5908 mL	1.1815 mL	2.9538 mL
	40 mM	0.0886 mL	0.4431 mL	0.8861 mL	2.2154 mL
	50 mM	0.0709 mL	0.3545 mL	0.7089 mL	1.7723 mL
	60 mM	0.0591 mL	0.2954 mL	0.5908 mL	1.4769 mL
	80 mM	0.0443 mL	0.2215 mL	0.4431 mL	1.1077 mL
	100 mM	0.0354 mL	0.1772 mL	0.3545 mL	0.8861 mL