2. Others Anti-infection
  3. Isotope-Labeled Compounds Parasite Antibiotic
  4. Diclazuril-d4

Diclazuril-d4  (Synonyms: R-64433-d4)

Cat. No.: HY-B0357S Purity: ≥98.0%
SDS COA Handling Instructions

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Diclazuril-d4 is deuterium labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al[1][2].

For research use only. We do not sell to patients.

Diclazuril-d<sub>4</sub> Chemical Structure

Diclazuril-d4 Chemical Structure

CAS No. : 1632495-80-7

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1 mg USD 730 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Diclazuril-d4:

Diclazuril-d4 Related Antibodies

Top Publications Citing Use of Products

View All Parasite Isoform Specific Products:

View All Isoforms
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

View All Antibiotic Isoform Specific Products:

View All Isoforms
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Diclazuril-d4 is deuterium labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al[1][2].

IC50 & Target

Coccidia

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diclazuril-d4 Related Antibodies
Molecular Weight

411.66

Formula

C17H5D4Cl3N4O2
CAS No.
Unlabeled CAS

101831-37-2
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N(N=CC(N1)=O)C2=CC(Cl)=C(C(Cl)=C2)C(C3=C([2H])C([2H])=C(C([2H])=C3[2H])Cl)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (60.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 25 mg/mL (60.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4292 mL 12.1459 mL 24.2919 mL
5 mM 0.4858 mL 2.4292 mL 4.8584 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (252 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.4292 mL 12.1459 mL 24.2919 mL 60.7297 mL
5 mM 0.4858 mL 2.4292 mL 4.8584 mL 12.1459 mL
10 mM 0.2429 mL 1.2146 mL 2.4292 mL 6.0730 mL
15 mM 0.1619 mL 0.8097 mL 1.6195 mL 4.0486 mL
20 mM 0.1215 mL 0.6073 mL 1.2146 mL 3.0365 mL
25 mM 0.0972 mL 0.4858 mL 0.9717 mL 2.4292 mL
30 mM 0.0810 mL 0.4049 mL 0.8097 mL 2.0243 mL
40 mM 0.0607 mL 0.3036 mL 0.6073 mL 1.5182 mL
50 mM 0.0486 mL 0.2429 mL 0.4858 mL 1.2146 mL
60 mM 0.0405 mL 0.2024 mL 0.4049 mL 1.0122 mL
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Diclazuril-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diclazuril-d41632495-80-7R-64433-d4Isotope-Labeled CompoundsParasiteAntibioticInhibitorinhibitorinhibit

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