Diclofenac-¹³C₆

Name: Diclofenac- 13 C 6
Brand: MedChemExpress
SKU: HY-15036S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-15036S1 Purity: ≥99.90%: FAQs
Data Sheet SDS COA Handling Instructions

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Diclofenac-¹³C₆ is the ¹³C₆ labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

For research use only. We do not sell to patients.

Diclofenac-<sup>13</sup>C<sub>6</sub> Chemical Structure

Diclofenac-¹³C₆ Chemical Structure

CAS No. : 1261393-71-8

Size	Price	Stock	Quantity
1 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Diclofenac-¹³C₆:

Diclofenac In-stock
Diclofenac-¹³C₆ sodium Get quote

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COX COX-1 COX-2 COX-3

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

302.10

Formula

C₈¹³C₆H₁₁Cl₂NO₂

CAS No.

1261393-71-8

Unlabeled CAS

15307-86-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C[13C]1=[13CH][13CH]=[13CH][13CH]=[13C]1NC2=C(Cl)C=CC=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (413.77 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3102 mL	16.5508 mL	33.1016 mL
5 mM	0.6620 mL	3.3102 mL	6.6203 mL
10 mM	0.3310 mL	1.6551 mL	3.3102 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.90%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (252 KB) Elemental Analysis Report (110 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [Content Brief]

[3]. Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80. [Content Brief]

[4]. Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3102 mL	16.5508 mL	33.1016 mL	82.7541 mL
	5 mM	0.6620 mL	3.3102 mL	6.6203 mL	16.5508 mL
	10 mM	0.3310 mL	1.6551 mL	3.3102 mL	8.2754 mL
	15 mM	0.2207 mL	1.1034 mL	2.2068 mL	5.5169 mL
	20 mM	0.1655 mL	0.8275 mL	1.6551 mL	4.1377 mL
	25 mM	0.1324 mL	0.6620 mL	1.3241 mL	3.3102 mL
	30 mM	0.1103 mL	0.5517 mL	1.1034 mL	2.7585 mL
	40 mM	0.0828 mL	0.4138 mL	0.8275 mL	2.0689 mL
	50 mM	0.0662 mL	0.3310 mL	0.6620 mL	1.6551 mL
	60 mM	0.0552 mL	0.2758 mL	0.5517 mL	1.3792 mL
	80 mM	0.0414 mL	0.2069 mL	0.4138 mL	1.0344 mL
	100 mM	0.0331 mL	0.1655 mL	0.3310 mL	0.8275 mL