Dideoxy-amanitin

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Dideoxy-amanitin (compound 2), an α-Amanitin (HY-19610) derivative, is a potent and selective RNA polymerase II allosteric inhibitor with an IC₅₀ value of 74.2 nM.

For research use only. We do not sell to patients.

Dideoxy-amanitin Chemical Structure

CAS No. : 58255-46-2

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Biological Activity
Purity & Documentation
References
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Description

Dideoxy-amanitin (compound 2), an α-Amanitin (HY-19610) derivative, is a potent and selective RNA polymerase II allosteric inhibitor with an IC₅₀ value of 74.2 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	1.3 μM Compound: Dideoxy amanitin	Cytotoxicity against chinese hamster CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against chinese hamster CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35696491]

In Vitro

Dideoxy-amanitin (compound 2; 0.078-20 μM; 24 h) has cell cytotoxicity in CHO (Chinese hamster ovary) cells with an IC₅₀ value of 0.3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	CHO (Chinese hamster ovary) cells
Concentration:	0.078-20 μM
Incubation Time:	24 hours
Result:	Decreased cell proliferation in a dose-depengdent manner.

Molecular Weight

886.97

Formula

C₃₉H₅₄N₁₀O₁₂S

CAS No.

58255-46-2

SMILES

C[C@H]([C@H](NC([C@@H]1C[C@@H](O)CN1C([C@@H]2CC(N)=O)=O)=O)C(N[C@@H](CC3=C(SC[C@H](N4)C(N2)=O)NC5=C3C=CC=C5)C(NCC(N[C@H](C(NCC4=O)=O)[C@@H](C)CC)=O)=O)=O)[C@@H](O)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matinkhoo K, et, al. Design, Synthesis, and Biochemical Evaluation of Alpha-Amanitin Derivatives Containing Analogs of the trans-Hydroxyproline Residue for Potential Use in Antibody-Drug Conjugates. Chemistry. 2021 Jul 16;27(40):10282-10292. [Content Brief]