2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Diflomotecan

Diflomotecan (BN 80915) is a potent and orally active inhibitor of topoisomerase I. Diflomotecan (BN 80915) causes enhanced plasma stability and has the superior preclinical anti-tumour activity compared with other established compounds.

For research use only. We do not sell to patients.

Diflomotecan Chemical Structure

Diflomotecan Chemical Structure

CAS No. : 220997-97-7

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Diflomotecan Related Antibodies

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Topoisomerase Topo I Topo II

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Description

Diflomotecan (BN 80915) is a potent and orally active inhibitor of topoisomerase I. Diflomotecan (BN 80915) causes enhanced plasma stability and has the superior preclinical anti-tumour activity compared with other established compounds[1][2].

IC50 & Target

topoisomerase I[1]
Clinical Trial
Molecular Weight

398.36

Formula

C21H16F2N2O4
CAS No.
SMILES

O=C(OC1)C[C@](O)(CC)C2=C1C(N3CC4=CC5=CC(F)=C(F)C=C5N=C4C3=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Diflomotecan Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diflomotecan220997-97-7BN 80915BN80915BN-80915Topoisomeraseoraltopoisomerase Iplasma stabilityanti-tumourpreclinicalInhibitorinhibitorinhibit

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