2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Dihomo-γ-linolenic acid-d6

Dihomo-γ-linolenic acid-d6  (Synonyms: DGLA-d6; all-cis-8,11,14-Eicosatrienoic acid-d6)

Cat. No.: HY-A0143S Purity: ≥99.0%
COA Handling Instructions

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Dihomo-γ-linolenic acid-d6 (DGLA-d6) is the deuterium labeled Dihomo-γ-linolenic acid. Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].

For research use only. We do not sell to patients.

Dihomo-γ-linolenic acid-d<sub>6</sub> Chemical Structure

Dihomo-γ-linolenic acid-d6 Chemical Structure

CAS No. : 81540-86-5

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Solvent
1 mg (3.20 mM * 1 mL in Methyl acetate) USD 750 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Dihomo-γ-linolenic acid-d6:

Dihomo-γ-linolenic acid-d6 Related Antibodies

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  • Purity & Documentation

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Description

Dihomo-γ-linolenic acid-d6 (DGLA-d6) is the deuterium labeled Dihomo-γ-linolenic acid. Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dihomo-γ-linolenic acid-d6 Related Antibodies
Molecular Weight

312.52

Formula

C20H28D6O2
CAS No.
Unlabeled CAS

1783-84-2
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\CCCCCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 100 mg/mL (319.98 mM)

DMSO : ≥ 100 mg/mL (319.98 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 100 mg/mL (319.98 mM)

Ethanol : ≥ 100 mg/mL (319.98 mM)

DMF : ≥ 100 mg/mL (319.98 mM)

DMSO : ≥ 100 mg/mL (319.98 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

0.15 M Tris-HCl pH 8.5 : ≥ 1 mg/mL (3.20 mM)

*"≥" means soluble, but saturation unknown.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.15 M Tris-HCl pH 8.5 / Ethanol / DMSO / DMF / Ethanol / DMF / DMSO 1 mM 3.1998 mL 15.9990 mL 31.9980 mL 79.9949 mL
Ethanol / DMSO / DMF / Ethanol / DMF / DMSO 5 mM 0.6400 mL 3.1998 mL 6.3996 mL 15.9990 mL
10 mM 0.3200 mL 1.5999 mL 3.1998 mL 7.9995 mL
15 mM 0.2133 mL 1.0666 mL 2.1332 mL 5.3330 mL
20 mM 0.1600 mL 0.7999 mL 1.5999 mL 3.9997 mL
25 mM 0.1280 mL 0.6400 mL 1.2799 mL 3.1998 mL
30 mM 0.1067 mL 0.5333 mL 1.0666 mL 2.6665 mL
40 mM 0.0800 mL 0.4000 mL 0.7999 mL 1.9999 mL
50 mM 0.0640 mL 0.3200 mL 0.6400 mL 1.5999 mL
60 mM 0.0533 mL 0.2666 mL 0.5333 mL 1.3332 mL
80 mM 0.0400 mL 0.2000 mL 0.4000 mL 0.9999 mL
100 mM 0.0320 mL 0.1600 mL 0.3200 mL 0.7999 mL
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Dihomo-γ-linolenic acid-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihomo-γ-linolenic acid-d681540-86-5DGLA-d6 all-cis-8,11,14-Eicosatrienoic acid-d6Endogenous MetaboliteInhibitorinhibitorinhibit

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